User:Mr. Ibrahem/Guselkumab
| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Human |
| Target | IL23 |
| Clinical data | |
| Trade names | Tremfya |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a617036 |
| License data |
|
| Pregnancy category |
|
| Routes of administration | Subcutaneous |
| Legal status | |
| Legal status | |
| Chemical and physical data | |
| Formula | C6402H9864N1676O1994S42 |
| Molar mass | 143561.59 g·mol−1 |
Guselkumab, sold under the brand name Tremfya, is a medication used to treat plaque psoriasis.[5][6] It is used for moderate to severe disease.[5] It is given by injection under the skin.[5]
Common side effects include upper respiratory tract infections.[5] Other side effects may include infection, headache, joint pain, liver problems, and decreased effectiveness of vaccines.[7] Safety in pregnancy is unclear.[7] It is a monoclonal antibody which attaches to and blocks interleukin-23.[5]
Guselkumab was approved for medical use in the United States and Europe in 2017.[7][5] In the United Kingdom it costs the NHS about £2,250 per 100 mg as of 2021.[8] This amount in the United States is about 11,600 USD.[9]
References
- ^ "Tremfya (Guselkumab) Australian Product Information". Department of Health, Therapeutic Goods Administration. The Australian Government. Archived from the original on 2021-06-13. Retrieved 2021-10-10.
- ^ "Tremfya 100 mg solution for injection in pre-filled pen - Summary of Product Characteristics (SmPC)". (emc). 1 November 2020. Archived from the original on 13 June 2021. Retrieved 12 June 2021.
- ^ "Tremfya- guselkumab injection". DailyMed. Archived from the original on 28 January 2021. Retrieved 22 January 2021.
- ^ "European Medicines Agency". European Medicines Agency {EMA). Retrieved 12 June 2021.
- ^ a b c d e f g "Tremfya". Archived from the original on 22 November 2021. Retrieved 9 December 2021.
- ^ a b "Guselkumab". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. National Institute of Diabetes and Digestive and Kidney Diseases. June 2018. PMID 31643594.
- ^ a b c d "Guselkumab Monograph for Professionals". Drugs.com. Archived from the original on 27 September 2021. Retrieved 9 December 2021.
- ^ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1302. ISBN 978-0857114105.
- ^ "Guselkumab Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 9 December 2021.