User:Mr. Ibrahem/Trifluridine
Appearance
Clinical data | |
---|---|
Trade names | Viroptic; Lonsurf (+tipiracil) |
Other names | α,α,α-trifluorothymidine; 5-trifluromethyl-2′-deoxyuridine; FTD5-trifluoro-2′-deoxythymidine; TFT; CF3dUrd; FTD; F3TDR; F3Thd |
AHFS/Drugs.com | Monograph |
License data | |
Routes of administration | Eye drops; tablets (+tipiracil) |
Drug class | Antiviral[1] |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | Negligible (eye drops); ≥57% (by mouth) |
Protein binding | >96% |
Metabolism | Thymidine phosphorylase |
Elimination half-life | 12 minutes (eye drops); 1.4–2.1 hrs (combination with tipiracil) |
Excretion | Mostly via urine |
Identifiers | |
| |
Chemical and physical data | |
Formula | C10H11F3N2O5 |
Molar mass | 296.202 g·mol−1 |
3D model (JSmol) | |
| |
| |
(what is this?) (verify) |
Trifluridine, also called trifluorothymidine (TFT) is an antiviral medication used to treat herpes simplex infections of the eye.[1] It may also be used for vaccinia infections of the eye that can occur following smallpox vaccination.[1] It is used as an eye drop.[1]
Common side effects include irrigation, eyelid swelling, and redness of the eyes.[1] It is believed to work by stopping the creation of viral DNA.[1]
Trifluridine was approved for medical use in the United States in 1980.[1][2] It is available as a generic medication and is also sold under the trade name Viroptic.[3][1] In the United States a 7.5 ml container costs about 74 USD.[3] It is also a component of the anti-cancer medication trifluridine/tipiracil.[4]
References
- ^ a b c d e f g h i j "Trifluridine Monograph for Professionals". Drugs.com. Archived from the original on 21 September 2021. Retrieved 19 September 2021.
- ^ Long, Sarah S.; Pickering, Larry K.; Prober, Charles G. (2012). Principles and Practice of Pediatric Infectious Disease. Elsevier Health Sciences. p. 1502. ISBN 978-1437727029. Archived from the original on 2019-12-29. Retrieved 2020-09-20.
- ^ a b "Viroptic Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 13 October 2016. Retrieved 19 September 2021.
- ^ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 969. ISBN 978-0-85711-369-6.
{{cite book}}
: CS1 maint: date format (link)