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PantherMyrtille/Marine Martin

Catégorie:Page utilisant P18 Catégorie:Article utilisant l'infobox Biographie2 Catégorie:Article utilisant une Infobox Marine Martin, born on June 26, 1972 in Toulouse, is a French whistleblower. She is the chairwomen of the Association d'Aide aux Parents d'Enfants souffrant du Syndrome de l'Anticonvulsivant ("APESAC"). She is also a patient expert at the ANSM and a member of the college of advisors of the journal Prescrire.

Biography

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In 2002, her son was born with malformations and neurobehavioral disorders, and she sought to understand the cause. In 2009, she discovered the link between Depakine and malformations/autism, thanks to the CRAT (Centre de Recherche des Agents Tératogènes / Teratogen Research Center) website. She then became a whistleblower[1] [2] [3] [4] for the Depakine[5] (Valproic acid) scandal, an anti-epileptic drug prescribed to women with epilepsy or bipolar disorder.

In 2011, she decided to create the association APESAC[6] based in Pollestres, to inform victims of the danger and alert the media and public authorities to change the conditions of prescription, impose pictograms on the boxes of drugs and demonstrate the transgenerational impact of Valproate by publishing a study at Birth Defects Research.

Positions taken

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Depakin Affair

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Since 2011, she has sought to denounce the Depakine scandal and in 2015, under the Touraine government, she obtained an investigation by the IGAS (General Inspectorate of Social Affairs)[7] [8] which pointed to the inertia of the Sanofi laboratory and the public authorities.

She sued Sanofi, with the help of her lawyer Charles Joseph-Oudin (who specializes in compensation for victims of health products and, more broadly, personal injury), in civil proceedings in 2012 and in criminal proceedings in 2015[9], and then sued the State in 2016 in the administrative court.

Her association APESAC was the first French health association to file a Class Action complaint in 2016[10][11][12]. In November 2016, she had a compensation scheme specifically dedicated to Depakine victims adopted by the ONIAM [13][14][15][16](Office National d'Indemnisation des Accidents Médicaux), as had been done for Mediator.

In April 2017, she released her book Dépakine, le Scandale: je ne pouvais pas me taire[17] [18] [19]with a preface by Irène Frachon, in which she recounts her struggle. She also published, alongside Catherine Hill, studies listing the number of victims of Depakine thanks to data from APESAC. This book was awarded a prize by the journal Prescrire the same year[20].

At the beginning of 2019, she will make public data collected within APESAC on the transgenerational impact of Depakine[21] [22] [23]that the children of Depakine children are likely to develop malformations or neurodevelopmental disorders[24]. At the same time, the work she undertook at the ANSM (Agence Nationale de Sécurité du Médicament et des Produits de Santé) is leading to a report, published in April 2019, classifying the danger of other antiepileptics in pregnant women[25][26][27].

In February 2020, the investigating judge in the criminal case indicted Sanofi for aggravated deception[28] and endangering[29] the lives of others, following the complaint filed by Marine Martin. In August of the same year, manslaughter was added to the charges[30], following the addition of four cases of deceased children. In October 2020, still in the context of the criminal case, the ANSM was indicted for endangering the lives of others and manslaughter[31].[32] In October 2021, Sanofi's request for the cancellation of the criminal report was rejected by the Paris investigating chamber, thus maintaining their indictment for "aggravated deception", "involuntary injury" and "involuntary manslaughter ".[33]

In December 2021, she publishes a study on the transgenerational impact of Valproate with the help of international scientists: Catherine Hill, Susan Bewley, Professor Emeritus of Obstetrics and Women's Health at King's College London, Alastair H. Maclennan, Director of the Cerebral Palsy Research Group at the University of Adelaide and Dr. Alain Braillon.

On January 5, 2022 her association APESAC won the first group action in health matters against SANOFI[34], judged responsible for a lack of vigilance and information on the risks of Depakine. The court found, among other things, that the French pharmaceutical group Sanofi had produced and marketed a defective product[35].

Institutional work

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In 2014, together with her British counterparts from the OACS (Organisation for Anti-convulsant Syndrome), she obtained the European re-evaluation of the drug at the EMA, imposed the implementation of a protocol based on that of Isotretinoin, and had the SPC [36] (Product Characteristics Summary) modified.

In 2016, she obtained from the ANSM that studies be carried out to determine the exact number of victims. Three reports were published: the first estimated the number of children born with malformations at 4,000 [37][38](published in 2016); the second stated that between 2007 and 2014: 14,000 women[39] had been pregnant on Depakin and that only 8,700 children had been born alive[40] (published in 2016). The last one states that 30,000 children have been born with neurobehavioral disorders in France since 1967 [41](2018).

In 2016, she negotiated to have pictograms placed on the boxes of Depakine[42], as well as on all so-called teratogenic drugs, warning of the dangers of the drug during pregnancy, which came out in April 2017 by decree[43], and then in 2018, she imposed it at European level.[44][45]

Marine Martin continues her fight, awaiting the various judgments. The whistleblower, who has become an expert patient at the ANSM, "remains in the crosshairs of Sanofi [...] which is trying to cancel her appointment ".[46]

In May 2021, Sanofi was refused by the administrative court of Montreuil, to have Marine Martin removed from her position as a patient expert at the ANSM.[47]

The same month, she and her association APESAC joined the Maison des Lanceurs d'Alerte

Bibliography

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Works

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  • Dépakine, le scandale. Je ne pouvais pas me taire, edition Robert Laffont[48], 2017
  • Enfant Dépakine[49], 2020

Articles

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  • Proposals for Engaging Patients and Healthcare Professionals in Risk Minimisation from an Analysis of Stakeholder Input to the EU Valproate Assessment Using the Novel Analysing Stakeholder Safety Engagement Tool (ASSET), in Drug Safety[50], july 2021
  • Transgenerational adverse effects of valproate? A patient report from 90 affected families in Birth Defects Reseach[51],[52], december 2021
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  • Effets indésirables - Victimes des médicaments, Clotilde Cadu, edition Hugo & Cie, 2016
  • Effets secondaires - Le scandale Français, Antoine Beguin et Jean-Christophe Brisard, édition First, 2016
  • Guide des 4000 médicaments utiles, inutiles ou dangereux, Bernard Debré and Philippe Even, edition Cherche Midi, 2016
  • Un député et son collab' chez Big Pharma, Cyril Pocréaux and François Ruffin, edition Fakir, 2018
  • Ce pays que tu ne connais pas, François Ruffin, edition Les Arènes, 2019
  • Les résistantes, Florence Méréo, edition HarperCollins, 2019
  • Mauvais traitements - Pourquoi les femmes sont mal soignées, Delphine Bauer and Ariane Puccini, edition Seuil, 2020
  • Les accords de Galéo, Salomé Martin, edition Sudarène Édition, 2019
  • Lanceurs d'alerte (bande dessinée), Flore Talamon - Bruno Loth, Delcourt (éditions), 2021
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References

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[[Category:Sanofi]] [[Category:Articles with authority control information]]

  1. ^ "Marine Martin, lanceuse d'alerte : "Je ne pouvais pas me taire"". Europe 1 (in French). Retrieved 2023-01-25.
  2. ^ "Marine Martin, lanceuse d'alerte : "Je ne pouvais pas me taire"". Europe 1 (in French). Retrieved 2023-01-25.
  3. ^ à 06h02, Par Elsa Mari Le 25 avril 2019 (2019-04-25). "Dépakine : le long combat de la lanceuse d'alerte Marine Martin". leparisien.fr (in French). Retrieved 2023-01-25.{{cite web}}: CS1 maint: numeric names: authors list (link)
  4. ^ à 09h42, Par Ariane Riou Le 22 novembre 2021 (2021-11-22). "Le parcours éprouvant des lanceurs d'alerte : «Parfois, je me demande pourquoi je me suis mise dans cette galère…»". leparisien.fr (in French). Retrieved 2023-01-25.{{cite web}}: CS1 maint: numeric names: authors list (link)
  5. ^ "Marine Martin, celle qui a mené le combat des victimes de la Dépakine - Elle". elle.fr (in French). 2017-04-15. Retrieved 2023-01-25.
  6. ^ "Un nouveau scandale autour d'un médicament ?". lindependant.fr (in French). Retrieved 2023-01-25.
  7. ^ "La Dépakine : à mères soignées, enfants handicapés". L'Humanité (in French). 2015-09-04. Retrieved 2023-01-25.
  8. ^ "Enquête relative aux spécialités pharmaceutiques contenant du valproate de sodium". igas.gouv.fr. {{cite web}}: |archive-date= requires |archive-url= (help); Check date values in: |archive-date= (help); External link in |url-status= (help); Invalid |url-status=https://igas.gouv.fr/IMG/pdf/2015-094R.pdf (help); Missing or empty |url= (help); line feed character in |title= at position 49 (help)
  9. ^ "Un antiépileptique dans la tourmente". sante.lefigaro.fr. 2015-05-20. Retrieved 2023-01-25.
  10. ^ AFP (2016-12-13). "Dépakine: lancement d'une action de groupe contre Sanofi". Challenges (in French). Retrieved 2023-01-25.
  11. ^ Favereau, Eric. "Scandale de la Dépakine : première action de groupe dans le domaine de la santé". Libération (in French). Retrieved 2023-01-25.
  12. ^ "Dépakine : Sanofi visé par la première action de groupe en matière de santé". Le Monde.fr (in French). 2016-12-13. Retrieved 2023-01-25.
  13. ^ à 08h21, Par Le 16 novembre 2016 (2016-11-16). "Scandale de la Dépakine : un fonds d'indemnisation pour les victimes". leparisien.fr (in French). Retrieved 2023-01-25.{{cite web}}: CS1 maint: numeric names: authors list (link)
  14. ^ www.legifrance.gouv.fr https://www.legifrance.gouv.fr/loda/id/JORFTEXT000034602550/. Retrieved 2023-01-25. {{cite web}}: Missing or empty |title= (help)
  15. ^ "Dépakine : l'Assemblée donne son feu vert au fonds d'indemnisation". Le Monde.fr (in French). 2016-11-16. Retrieved 2023-01-25.
  16. ^ Marianne, Magazine (2016-11-16UTC09:20:00+0100). "Dépakine : l'Assemblée autorise à faire payer Sanofi pour les victimes". www.marianne.net (in French). Retrieved 2023-01-25. {{cite web}}: Check date values in: |date= (help)
  17. ^ "Dépakine : « On a laissé des femmes malades prendre le risque d'avoir des enfants malades »". Le Monde.fr (in French). 2017-05-17. Retrieved 2023-01-25.
  18. ^ "Scandale de la Dépakine : les années de combat d'une épileptique". sante.lefigaro.fr. 2017-04-10. Retrieved 2023-01-25.
  19. ^ "Dépakine, le combat d'une mère". Le Monde.fr (in French). 2017-06-03. Retrieved 2023-01-25.
  20. ^ "Dépakine° le scandale. Je ne pouvais pas me taire". www.prescrire.org. Retrieved 2023-01-25.
  21. ^ Maziere, Mélanie (23 avril april 2019). "Dépakine : les petits-enfants aussi ?". Le Quotidien du Pharmacien. {{cite web}}: Check |archive-url= value (help); Check date values in: |date= (help)
  22. ^ Saint, Rozenn Le. "Les petits-enfants Dépakine: une nouvelle génération de victimes du médicament?". Mediapart (in French). Retrieved 2023-01-25.
  23. ^ Le Saint, Rozenn (22 avril 2019). "Les petites-enfants Dépakine : une nouvelle génération de victimes du médicament ?" (PDF). apesac.org (PDF). {{cite web}}: Check |archive-url= value (help); Check date values in: |date= (help)
  24. ^ "Le scandale de la Dépakine, Valproate, affecte aussi la 2eme génération". {{cite web}}: Check |archive-url= value (help)
  25. ^ à 06h02, Par Elsa Mari Le 25 avril 2019 (2019-04-25). "Dépakine : le long combat de la lanceuse d'alerte Marine Martin". leparisien.fr (in French). Retrieved 2023-01-25.{{cite web}}: CS1 maint: numeric names: authors list (link)
  26. ^ "Malformations : après la Dépakine, le risque d'autres antiépileptiques". Le Monde.fr (in French). 2019-04-24. Retrieved 2023-01-25.
  27. ^ "Antiépileptiques au cours de la grossesse : Etat actuel des connaissances sur le risque de malformations et de troubles neuro-développementaux" (PDF). apesac.org (PDF). {{cite web}}: |first= missing |last= (help); Check |archive-url= value (help)
  28. ^ "Sanofi investigated over epilepsy drug linked to birth defects". Reuters. 2020-02-04. Retrieved 2023-01-25.
  29. ^ "Dépakine : le laboratoire Sanofi annonce sa mise en examen pour "tromperie aggravée" et "blessures involontaires"". Franceinfo (in French). 2020-02-03. Retrieved 2023-01-25.
  30. ^ "Dépakine : Sanofi mis en examen pour homicides involontaires". Le Monde.fr (in French). 2020-08-03. Retrieved 2023-01-25.
  31. ^ "Dépakine : Sanofi mis en examen pour homicides involontaires". Le Monde.fr (in French). 2020-08-03. Retrieved 2023-01-25.
  32. ^ "Scandale de la Dépakine : l'Agence du médicament mise en examen pour « homicides involontaires »". Le Monde.fr (in French). 2020-11-09. Retrieved 2023-01-25.
  33. ^ "Dépakine : l'expertise médicale qui accuse Sanofi est validée par les juges - Association d'Aide aux Parents d'Enfants souffrant du Syndrome de l'Anti-Convulsivant". apesac.org. Retrieved 2023-01-25.
  34. ^ Salaün, Tangi (2022-01-05). "French court backs class action against Sanofi over Depakine drug". Reuters. Retrieved 2023-01-25.
  35. ^ "Dépakine : Sanofi jugé responsable d'un manque de vigilance et d'information sur les risques". Le Monde.fr (in French). 2022-01-05. Retrieved 2023-01-25.
  36. ^ ""Victoire" contre un antiépileptique - Association d'Aide aux Parents d'Enfants souffrant du Syndrome de l'Anti-Convulsivant". www.apesac.org. Retrieved 2023-01-25.
  37. ^ "Call for audit of pregnant women who took anti-epilepsy drug". The Irish Times. Retrieved 2023-01-25.
  38. ^ "Dépakine : 2 000 à 4 000 cas de malformations majeures". France Inter (in French). 2017-04-20. Retrieved 2023-01-25.
  39. ^ "Over 14,000 women took Sanofi epilepsy drug despite fetus risk: ministry". Reuters. 2016-08-24. Retrieved 2023-01-25.
  40. ^ "Rapport étude VPA" (PDF). apesac.org (PDF). {{cite web}}: Check |archive-url= value (help)
  41. ^ "Une étude confirme l'ampleur des dégâts causés par la Dépakine". Le Monde.fr (in French). 2018-06-22. Retrieved 2023-01-25.
  42. ^ "Marine Martin, figure de proue des victimes de la Dépakine". L'Express (in French). 2017-04-07. Retrieved 2023-01-25.
  43. ^ Julia, Véronique (2017-10-17). "Des pictogrammes sur les médicaments pour alerter les femmes enceintes". France Inter (in French). Retrieved 2023-01-25.
  44. ^ "Intervention Marine Martin EMA valproate". youtube.com. {{cite web}}: Check |archive-url= value (help)
  45. ^ "New measures to avoid valproate exposure in pregnancy endorsed" (PDF). ema.europa.eu, (PDF). {{cite web}}: Check |archive-url= value (help); line feed character in |title= at position 54 (help)CS1 maint: extra punctuation (link)
  46. ^ Eschapasse, Baudouin (2020-02-07). "Dépakine : une lanceuse d'alerte dans le collimateur de Sanofi". Le Point (in French). Retrieved 2023-01-25.
  47. ^ "Scandale de la Dépakine : la justice déboute le groupe pharmaceutique Sanofi". Le Monde.fr (in French). 2021-05-20. Retrieved 2023-01-25.
  48. ^ "Dépakine, le scandale. Je ne pouvais pas me taire". lisez.com. 06 avril 2017. {{cite web}}: Check date values in: |date= (help)
  49. ^ "Enfants Dépakine". apesac.org. 4 juin 2020. {{cite web}}: Check date values in: |date= (help)
  50. ^ "Proposals for Engaging Patients and Healthcare Professionals in Risk Minimisation from an Analysis of Stakeholder Input to the EU Valproate Assessment Using the Novel Analysing Stakeholder Safety Engagement Tool (ASSET)". link.springer.com. juillet 2021. {{cite web}}: Check date values in: |date= (help)
  51. ^ Martin, Marine; Hill, Catherine; Bewley, Susan; MacLennan, Alastair H. "Transgenerational adverse effects of valproate? A patient report from 90 affected families". Birth Defects Research. doi:10.1002/bdr2.1967. ISSN 2472-1727. Retrieved 2021-12-10.
  52. ^ "La Dépakine pourrait avoir des effets toxiques sur plusieurs générations". www.20minutes.fr (in French). Retrieved 2021-12-10.
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