User:Petersam/drugs
Statin equivalents[edit]
Statins differ in their ability to reduce cholesterol. Doses should be individualized according to patient characteristics such as goal of therapy and response. After initiation and/or dose changes, lipid levels should be analyzed within 1-3 months and dosage adjusted accordingly, then every 6-12 months afterwards. [1] [2] [3] [4]
| Statin Equivalent Dosages | ||||||
|---|---|---|---|---|---|---|
| % LDL Reduction (approx.) | Atorvastatin | Fluvastatin | Lovastatin | Pravastatin | Rosuvastatin | Simvastatin |
| 10-20% | -- | 20 mg | 10 mg | 10 mg | -- | 5 mg |
| 20-30% | -- | 40 mg | 20 mg | 20 mg | -- | 10mg |
| 30-40% | 10 mg | 80 mg | 40 mg | 40 mg | 5 mg | 20 mg |
| 40-45% | 20 mg | -- | 80 mg | 80 mg | 5-10 mg | 40 mg |
| 46-50% | 40 mg | -- | -- | -- | 10-20 mg | 80 mg |
| 50-55% | 80 mg | -- | -- | -- | 20 mg | -- |
| 56-60% | -- | -- | -- | -- | 40 mg | -- |
| Starting dose | ||||||
| Starting dose | 10-20 mg | 20 mg | 10-20 mg | 40 mg | 10 mg; 5 mg if hypothyroid, >65 yo, Asian; | 20 mg |
| If higher LDL reduction goal | 40 mg if >45% | 40 mg if >25% | 20 mg if >20% | -- | 20 mg if LDL >190 | 40 mg if >45% |
| Optimal timing | Anytime | Evening | With evening meals | Anytime | Anytime | Evening |
ACEI equivalents[edit]
Equivalent daily doses of ACE inhibitors. Dosage should be adjusted according to the blood pressure response. [5] [6] [7]
| ACE inhibitors dosages for hypertension | |||||
|---|---|---|---|---|---|
| Dosage | |||||
| Name | Equivalent daily dose | Start | Usual | Maximum | |
| Benazepril | 10 mg | 10 mg | 20-40 mg | 80 mg | |
| Captopril | 50 mg (25 mg bid) | 12.5-25 mg bid-tid | 25-50 mg bid-tid | 450 mg/d | |
| Enalapril | 5 mg | 5 mg | 10-40 mg | 40 mg | |
| Fosinopril | 10 mg | 10 mg | 20-40 mg | 80 mg | |
| Lisinopril | 10 mg | 10 mg | 10-40 mg | 80 mg | |
| Moexipril | 7.5 mg | 7.5 mg | 7.5-30 mg | 30 mg | |
| Perindopril | 4 mg | 4 mg | 4-8 mg | 16 mg | |
| Quinapril | 10 mg | 10 mg | 20-80 mg | 80 mg | |
| Ramipril | 2.5 mg | 2.5 mg | 2.5-20 mg | 20 mg | |
| Trandolapril | 2 mg | 1 mg | 2-4 mg | 8 mg | |
| Note: bid = 2 times a day, tid = 3 times a day, d = daily Drug dosages from Drug Lookup, Epocrates Online. | |||||
References[edit]
- Laura Dean, MD. December 1, 2007. Comparing Statins, The "Drug Class Review on HMG-CoA Reductase Inhibitors (Statins)" compares the safety and effectiveness of six statins. A summary of the findings is presented. Summaries of key questions from the Drug Effectiveness Review Project (DERP), Oregon Health & Science University
- ^ Ryan Oftebro, PharmD. HMG-CoA Reductase Inhibitors (“Statins”): Clinical Pearls for Washington Rx Therapeutic Interchange Program (TIP). Accessed 2009-11-22.
- ^ Common Medication Conversions (Equivalents): Statins (HMG-CoA Reductase Inhibitors) GlobalRPh.com. Accessed 2009-11-22.
- ^ Treating Elevated Cholesterol and Heart Disease: The Statins. Consumer Reports Health Best Buy Drugs. February 2007
- ^ Dosage information including FDA approved labels (package inserts) from DailyMed United States National Library of Medicine.
- ^ What are the dose comparisons of all ACE inhibitors used in hypertension? TripAnswers TRIP Database, May 25, 2007. Accessed 2009-11-21
- ^ Common Medication Conversions (Equivalents): Ace Inhibitors. GlobalRPh.com. Accessed 2009-11-22.
- ^ Treating High Blood Pressure and Heart Disease: the ACE Inhibitors. Consumer Reports Health Best Buy Drugs. June 2009.