User:Petersam/statin
http://en.wikipedia.org/wiki/Statin
Statin equivalents
[edit]Statins differ in their ability to reduce cholesterol. Doses should be individualized according to patient characteristics such as goal of therapy and response. After initiation and/or dose changes, lipid levels should be analyzed within 1-3 months and dosage adjusted accordingly, then every 6-12 months afterwards. [1] [2] [3] [4]
| Statin Equivalent Dosages | |||||||
|---|---|---|---|---|---|---|---|
| % LDL Reduction (approx.) | Atorvastatin | Fluvastatin | Lovastatin | Pitavastatin | Pravastatin | Rosuvastatin | Simvastatin |
| 10-20% | -- | 20 mg | 10 mg | -- | 10 mg | -- | 5 mg |
| 20-30% | -- | 40 mg | 20 mg | 1 mg | 20 mg | -- | 10mg |
| 30-40% | 10 mg | 80 mg | 40 mg | 2 mg | 40 mg | 5 mg | 20 mg |
| 40-45% | 20 mg | -- | 80 mg | 4 mg | 80 mg | 5-10 mg | 40 mg |
| 46-50% | 40 mg | -- | -- | -- | -- | 10-20 mg | 80 mg |
| 50-55% | 80 mg | -- | -- | -- | -- | 20 mg | -- |
| 56-60% | -- | -- | -- | -- | -- | 40 mg | -- |
| Starting dose | |||||||
| Starting dose | 10-20 mg | 20 mg | 10-20 mg | 2 mg | 40 mg | 10 mg; 5 mg if hypothyroid, >65 yo, Asian; | 20 mg |
| If higher LDL reduction goal | 40 mg if >45% | 40 mg if >25% | 20 mg if >20% | -- | -- | 20 mg if LDL >190 | 40 mg if >45% |
| Optimal timing | Anytime | Evening | With evening meals | Anytime | Anytime | Anytime | Evening |
References
[edit]- Laura Dean, MD. December 1, 2007. Comparing Statins, The "Drug Class Review on HMG-CoA Reductase Inhibitors (Statins)" compares the safety and effectiveness of six statins. A summary of the findings is presented. Summaries of key questions from the Drug Effectiveness Review Project (DERP), Oregon Health & Science University
- Pitavastatin (Livalo) - The Seventh Statin. The Medical Letter, July 26, 2010; (1343) pp. 57-58
- ^ Ryan Oftebro, PharmD. HMG-CoA Reductase Inhibitors (“Statins”): Clinical Pearls for Washington Rx Therapeutic Interchange Program (TIP). Accessed 2009-11-22.
- ^ Common Medication Conversions (Equivalents): Statins (HMG-CoA Reductase Inhibitors) GlobalRPh.com. Accessed 2009-11-22.
- ^ Treating Elevated Cholesterol and Heart Disease: The Statins. Consumer Reports Health Best Buy Drugs. February 2007
- ^ Dosage information including FDA approved labels (package inserts) from DailyMed United States National Library of Medicine.