User:Purplemountain1/sandboxMA

According to

Wikipedia:Manual of Style/Medicine-related articles#Drugs, treatments, and devices

the suggested outline should follow:

(following list of suggested headings contains wikilinks; the actual headings should not).

• Medical uses (how the intervention is used, along with evaluations of efficacy if available)
• Contraindications
• Adverse effects (may include "addiction", "dependence", or "withdrawal") or Side effects
• Overdose (including toxicity caused by overdose)
• Drug interactions or Interactions
• Pharmacology
  • Mechanism of action or Pharmacodynamics
  • Pharmacokinetics (cover absorption, distribution, metabolism and excretion)
  • Pharmacomicrobiomics (if known, cover any clinically significant drug-microbiota interactions)
• Chemistry (for drugs)
  • Synthesis: Content should be encyclopedic, not instructional or pedagogical, and should include content and a source explaining the relevance of the synthesis information provided (the first, the one used to manufacture the drug, etc.).
  • Detection in body fluids
• Manufacturing
• History
• Society and culture
  • Legal status
  • Recreational use
  • Economics
  • Brand names
• Research: Include only if addressed by significant sources. See Trivia, and avoid useless statements like "More research is needed". Wikipedia is not a directory of clinical trials or researchers. Avoid promotional descriptions of early-stage interventions.
• Veterinary use or other animals

actual TOC currently as of 9/11/19:

FOR SECTION ON MEDICAL USES meaning: how the intervention is used, along with evaluations of efficacy if available

According to a systematic review of 33,846 women across 20 studies, the success rate of mifepristone followed by misoprostol through 10 weeks pregnancy is 96.6%. Reference: Chen, M. J., & Creinin, M. D. (2015). Mifepristone with buccal misoprostol for medical abortion: A systematic review. Obstetrics & Gynecology, 126(1), 12-21.

from CURHs:

A 2019 systematic review assessed effectiveness of misoprostol alone by reviewing 42 studies where at least one group of women received misoprostol alone to induce abortion; however, the misoprostol regimens differed across the studies. The review, which included 12,829 women, found an overall abortion success rate of 78% (Raymond et al, 2019).

reword:

According to a systematic review of 12,829 women across 42 studies, the success rate of misoprostol alone for first trimester abortion is 78%. reference: Raymond, E., Harrison, M, & Weaver, M. (2019). Efficacy of misoprostol alone for first-trimester medical abortion: A systematic review. Obstetrics & Gynecology, 133, 137-147.

Under Side effects/adverse effects add:

Most women will have cramping and bleeding heavier than a menstrual period. Nausea, vomiting, diarrhea, headache, dizziness, and fever/chills are also common. Misoprostol taken vaginally tends to have fewer gastrointestinal side effects. Nonsteroidal antiinflammatory medications such as ibuprofen reduce pain with medication abortion.

Under pharamacology section add:

Medical contraindications to mifepristone are rare and include ectopic pregnancy, intrauterine device in place, chronic corticosteroid use, adrenal failure, bleeding disorder, and allergy to mifepristone. Misoprostol is contraindicated in women who are alllergic to it. Many studies excluded women with severe medical problems such as heart and liver disease or severe anemia.

under medical uses:

For medical abortion prior to 12 weeks gestation, the WHO recommends mifepristone 200 mg by mouth followed 1-2 days later by misoprostol 800 mcg inside the cheek, vaginally, or under the tongue; misoprostol may be repeated to maximize success. The success rate of mifepristone followed by misoprostol through 10 weeks pregnancy is 96.6%.(WHO REFERENCE is there already) ADD: In another large review of more than 45,000 women receiving mifepristone followed by misoprostol through various routes, the overall success rate was over 95% with 1.1% experiencing ongoing pregnancy. (Raymond 2013)

under Methods, first bullet mife/miso add:

Women who take misoprostol less than 24 hours after mifepristone have higher failures rates compared to women who waited 1-2 days.(Raymond 2013)