User:Rl1415/sandbox
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Microfibrils are part of the hierarchy in the molecular assembly of biological fibers. During the assembly, mirofibrils exhibit a repeating stringed-beads pattern produced by the cross-linking of molecules forming a striated pattern described in its periodicity.
Fibrillin[edit]
Fibrillin microfibrils are found in connective tissues, mainly composed of fibrillin-1[1] and providing elasticity. In the formation of elastic fiber, fibrillin microfibrils guides the deposit of tropoelastin and remains in the outer layer of mature elastin fibers.[2] The microfibril is also associated in cell communication. Formation of fibrillin microfibrils in the pericellular region affects the activity of a growth factor called TGFβ.
There is an increase in TGFβ activity associated with Marfan Syndrome due to the mutation of fibrillin-1.[1]
| This is a user sandbox of Rl1415. You can use it for testing or practicing edits. This is not the sandbox where you should draft your assigned article for a dashboard.wikiedu.org course. To find the right sandbox for your assignment, visit your Dashboard course page and follow the Sandbox Draft link for your assigned article in the My Articles section. |
- ^ a b Massam-Wu, Teresa; Chiu, Maybo; Choudhury, Rawshan; Chaudhry, Shazia S.; Baldwin, Andrew K.; McGovern, Amanda; Baldock, Claire; Shuttleworth, C. Adrian; Kielty, Cay M. (2010). "Assembly of fibrillin microfibrils governs extracellular deposition of latent TGFβ" (PDF). J Cell Sci. 123: 3006–3018. doi:10.1242/jcs.073437 – via JCS.
- ^ Kielty, Cay M.; Baldock, Claire; Lee, David; Rock, Matthew J.; Ashworth, Jane L.; Shuttleworth, C. Adrian (28 February 2002). "Fibrillin: from microfibril assembly to biomechanical function" (PDF). Philos Trans R Soc Lond B Biol Sci. 357 (1148): 207–217. doi:10.1098/rstb.2001.1029 – via NCBI.