User:Ruwan23/sandbox
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Outline
- History
- MWC model
- emergence of KNF model by Koshland et al.
- Rules guiding the KNF model
- induced-fit model: change in conformation of enzyme to improve binding affinity to transition state, catalyzing reaction
- KNF model is conducive to this, where each ligand binding site changes affinity to the ligand, or the transition state of the ligand in the case of catalysis
- Comparison to the MWC model
- KNF predicts negative and mixed cooperativity, not possible with the MWC model
- T and R state vs. induced fit
- Adherence to Biochemical Data
- Hemoglobin by the MWC model
- hemoglobin by the KNF model