User:Znchtt/Sulforaphane
Sulforaphane has two possible stereoisomers due to the presence of a stereogenic Sulfur atom.[1]
The R-SFN enantiomer occurs naturally, while the S-SFN can be synthesized.[2]
Studies in vitro demonstrate that SFN regulate actin cytoskeleton, inhibiting the formation of actin stress fiber and the expression of associated proteins which promotes the spread of premalignant cells. Therefore, the studies shown that SFN suppresses metastasis of breast cancer.[3]
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References[edit]
- ^ Janczewski, Łukasz (2022-03-07). "Sulforaphane and Its Bifunctional Analogs: Synthesis and Biological Activity". Molecules (Basel, Switzerland). 27 (5): 1750. doi:10.3390/molecules27051750. ISSN 1420-3049. PMC 8911885. PMID 35268851.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Zhang, Ying; Lu, Qian; Li, Nan; Xu, Ming; Miyamoto, Tatsuo; Liu, Jing (2022-03-24). "Sulforaphane suppresses metastasis of triple-negative breast cancer cells by targeting the RAF/MEK/ERK pathway". npj Breast Cancer. 8 (1): 1–14. doi:10.1038/s41523-022-00402-4. ISSN 2374-4677.
- ^ Zhang, Ying; Lu, Qian; Li, Nan; Xu, Ming; Miyamoto, Tatsuo; Liu, Jing (2022-03-24). "Sulforaphane suppresses metastasis of triple-negative breast cancer cells by targeting the RAF/MEK/ERK pathway". npj Breast Cancer. 8 (1): 1–14. doi:10.1038/s41523-022-00402-4. ISSN 2374-4677.