User talk:73.102.68.190

Greetings, these remarks are to the current author(s): Kudos to an excellent job on the Pancreas article and graphics. Much better than previous attempts. The best WIKI article I have seen in several years. However, a few parts need further illumination, in the light of knowledge that is easily found from many sources,(sciencenews.org, usually) but not yet compiled through a central node. 1. The beta cells produce GABA concurrent with insulin. Internally, the pancreas uses this dampening neurotransmitter in a chemical fashion: It fits into a receptor on the surface of the Alpha cells, preventing them from producing Glucagon until such a time as insulin production levels have ceased, and the GABA is metabolized for energy. This provides two functions: It is a control interlock, and also provides hysteresis in the blood sugar control cycle. 2. Interestingly, the duodenum is also rich in GABA receptors, that are connected not only to Vagus, but also directly to the brain. These are heavily influenced by food and microbiotic sources of GABA. 3. The action of the duodenum, with its myriad receptors, via the sympathetic and parasympathetic nerves systems are also very influential in the operation of the pancreas. While I agree the liver interconnections are vital to the production of the correct digestive fluids, I note the interconnections with the duodenum are just as vital to the control of blood sugar as well. And with Glucagon's action considered, we now have three-way communications between the three organs in the control of blood sugar levels. Best Regards: David Seal

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