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Van Stadens River is a river in the Eastern Cape province of South Africa. The river mouth is located about 30 km west of Port Elizabeth.
The Van Stadens Bridge where the N2 national highway crosses the river is known as a suicide location.
Just upstream of the N2 bridge, the 2 foot (610 mm) gauge Avontuur Railway crosses the Van Stadens River over a 255 feet (78 m) high bridge.