Vermistatin
Appearance
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Names | |
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Preferred IUPAC name
(3R)-4,6-Dimethoxy-3-{4-oxo-6-[(1E)-prop-1-en-1-yl]-4H-pyran-3-yl}-2-benzofuran-1(3H)-one | |
Other names
5-(4,6-Dimethoxyphthalidyl)-2-propenyl-4H-pyran-4-one
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Identifiers | |
3D model (JSmol)
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ChEMBL | |
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PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C18H16O6 | |
Molar mass | 328.320 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Vermistatin is an organic compound and a metabolite of mine-dwelling Penicillium vermiculatum found in Berkeley Pit Lake, Butte, Montana.[1] Penisimplicissin is a vermistatin analog with anticancer activity.[2]
References
[edit]- ^ Fuska, J; Uhrín, D; Proksa, B; Votický, Z; Ruppeldt, J (1986). "The structure of vermistatin, a new metabolite from Penicillium vermiculatum". The Journal of Antibiotics. 39 (11): 1605–8. doi:10.7164/antibiotics.39.1605. PMID 3793630.
- ^ Stierle AA, Stierle DB, Girtsman T (2012). "Caspase-1 inhibitors from an extremophilic fungus that target specific leukemia cell lines". J Nat Prod. 75 (3): 344–50. doi:10.1021/np200414c. PMC 3330824. PMID 22295871.