Vesiculobullous disease
| Vesiculobullous disease | |
|---|---|
| Specialty | Dermatology  |
A vesiculobullous disease is a type of mucocutaneous disease that is characterized by vesicles and bullae (i.e. blisters). Both vesicles and bullae are fluid-filled lesions, and they are distinguished by size (vesicles being less than 5-10 mm and bulla being larger than 5-10 mm, depending upon what definition is used). In the case of vesiculobullous diseases which are also immune disorders, the term immunobullous,[1] is sometimes used. Example vesiculobullous diseases include:
- Infectious: (viral)
- Herpes simplex
- Varicella-Zoster infection
- Hand, foot and mouth disease
- Herpangina
- Measles (Rubeola)
- Immunobullous:
- Pemphigus vulgaris[2]
- Pemphigoid
- Dermatitis herpetiformis[1]
- Linear immunoglobulin-A disease (linear IgA disease)
- Genetic:
Some features are as follows:
| Name | Acantholysis? | Ig |
|---|---|---|
| epidermolysis bullosa | yes | mostly IgG |
| bullous pemphigoid | no | mostly IgG |
| dermatitis herpetiformis | no | IgA |
References
- ^ Magro, C. M.; Roberts-Barnes, J.; Crowson, A. N. (2012). "Direct Immunofluorescence Testing in the Diagnosis of Immunobullous Disease, Collagen Vascular Disease, and Vascular Injury Syndromes". Dermatologic Clinics. 30 (4): 763–798, viii. doi:10.1016/j.det.2012.06.008. PMID 23021058.
- ^ Williams DM (December 1989). "Vesiculobullous mucocutaneous disease: pemphigus vulgaris". J. Oral Pathol. Med. 18 (10): 544–53. PMID 2695619.
- ^ Rao R, Prabhu SS, Sripathi H, Gupta S (2008). "Vesiculobullous lesions in lipoid proteinosis: a case report". Dermatol. Online J. 14 (7): 16. PMID 18718200.
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