Between 1907 and 1912, he published the first Romanian astronomical journal, Orion and in 1908, he was the founder of the Societatea astronomică română "Camille Flammarion". In 1912, Anestin became the director of the Ziarul Călătoriilor, which he renamed in Ziarul ştiinţelor populare ("Journal of Popular Sciences") and its circulation rose to 15,000. Together with C. I. Istrati, he founded Universitatea Populară din Bucureşti in 1912 and at the end of the year 1913, he founded the Prietenii Ṣtiinţei association.
Anestin wrote three science fiction novels and a large number of articles and over a hundred booklets about science.
In his novel A Celestial Tragedy (published in February 1914), Anestin has one of the earliest descriptions of the possibility of using the atomic power for war purposes, being published in the same year as H. G. Wells' The World Set Free.
In physics, they have managed to go to the roots of the structure of matter; moreover, at present, they make use of intra-atomic power [...] They have used this extraordinary power in wars as well; but, because of its disastrous effects, the states have signed a convention under which they pledge to use it for scientific purposes alone.”
The astronomical observatory of Bacău bears his name.
Science fiction novels
- În anul 4000 sau O călătorie la Venus (In the year 4000, or A trip to Venus, 1899, not to be confused with John Munro's A Trip to Venus, 1897)
- O tragedie cerească, Poveste astronomică (A Celestial Tragedy, An Astronomical Story, 1914)
- Puterea ştiinţei, sau Cum a fost omorât Răsboiul European, Poveste fantastică (The Power of Science, or How was the European War Killed, Fantasy Story, 1916)
- Florin Manolescu, Literatura S.F., Editura Univers, Bucharest, 1980