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Wang Shizhen is the name of:
- Wang Shizhen (Tang dynasty) (759–809), Tang dynasty warlord, de facto ruler of Chengde
- Wang Shizhen (Ming dynasty) (1526–1590), Ming dynasty poet, writer, artist and litterateur.
- Wang Shizhen (Beiyang government) (1861–1930), general and minister of the Beiyang government of Republic of China
- Wang Shizhen (physician) (1916–2016), founder of Chinese nuclear medicine
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