William Harvey

For other people named William Harvey, see William Harvey (disambiguation).

William Harvey
William Harvey
Born	1 April 1578 Folkestone, England
Died	3 June 1657(1657-06-03) (aged 79) Roehampton, London, England
Nationality	English
Alma mater	Gonville and Caius College, Cambridge University of Padua
Known for	De Motu Cordis (on Circulation of the blood)
Scientific career
Fields	Medicine Anatomy
Doctoral advisor	Hieronymus Fabricius
Signature

William Harvey (1 April 1578 – 3 June 1657) was an English physician who made seminal contributions in anatomy and physiology. He was the first known to describe completely and in detail the systemic circulation and properties of blood being pumped to the brain and body by the heart, though earlier writers, such as Realdo Colombo, Miguel Servet (aka Michael Servetus, Michel de Villeneuve) in: Christianismi Restitutio, Paris, 1546, and Jacques Dubois, had provided precursors of the theory. In 1973 the William Harvey Hospital was constructed in the town of Ashford, several miles from his birthplace of Folkestone.

Family

William's father, Thomas Harvey, was a jurat of Folkestone where he served the office of mayor in 1600. Records and personal descriptions delineate him as an overall calm, diligent, and intelligent man whose "sons... revered, consulted and implicitly trusted in him... (they) made their father the treasurer of their wealth when they acquired great estates...(He) kept, employed, and improved their gainings to their great advantage." Thomas Harvey's portrait can still be seen in the central panel of a wall of the dining-room at Rolls Park, Chigwell, in Essex. William was the eldest of nine children, seven sons and two daughters, of Thomas and his wife Joan Halke. Notable family connections include Heneage Finch, 1st Earl of Nottingham, who married William's niece Elizabeth Harvey, and the diplomat Sir Daniel Harvey.

Biography

Early life and the University of Padua

Harvey's initial education was carried out in Folkestone, where he learned Latin. He then entered the King's School (Canterbury). Harvey stayed at the King's School for five years, after which he joined Gonville and Caius College in Cambridge in 1593.

Harvey graduated as a Bachelor of Arts from Caius in 1597. He then traveled through France and Germany to Italy, where he entered the University of Padua, in 1599.

During Harvey's years of study there, he developed a relationship with Fabricius and read Fabricius' De Venarum Ostiolis.

Harvey graduated as a Doctor of Medicine at the age of 24 from the University of Padua on 25 April 1602. It reports that Harvey had

"conducted himself so wonderfully well in the examination and had shown such skill, memory and learning that he had far surpassed even the great hopes which his examiners had formed of him."

The College of Physicians, Marriage and Saint Bartholomew's Hospital

After graduating from Padua, Harvey immediately returned to England where he obtained the degree of Doctor of Medicine from the University of Cambridge that same year, and became a fellow of Gonville and Caius College. Following this, Harvey established himself in London, joining the College of Physicians on 5 October 1604.

A few weeks after his admission, Harvey married Elizabeth Browne, "daughter of Lancelot Browne Dr. Physic". They had no children.

Elected a Fellow of the College of Physicians on 5 June 1607, Harvey accepted a position at St Bartholomew's Hospital that he was to occupy for almost all the rest of his life. Succeeding a Dr Wilkinson on 14 October 1609, he became the Physician in charge at St Bartholomew's Hospital, which enjoined him, "in God's most holy name" to "endeavor yourself to do the best of your knowledge in the profession of physic to the poor then present, or any other of the poor at any time of the week which shall be sent home unto you by the Hospitaller... You shall not, for favor, lucre or gain, appoint or write anything for the poor but such good and wholesome things as you shall think with your best advice will do the poor good, without any affection or respect to be had to the apothecary. And you shall take no gift or reward... for your counsel... This you will promise to do as you shall answer before God... "

Harvey earned around thirty-three pounds a year and lived in a small house in Ludgate, although two houses in West Smithfield were attached as fringe benefits to the post of Physician. At this point, the physician's function consisted of a simple but thorough analysis of patients who were brought to the hospital once a week and the consequent writing of prescriptions.

Lumleian Lecturer

The next important phase of Harvey's life began with his appointment to the office of Lumleian lecturer on 4 August 1615. The Lumleian lectureship, founded by Lord Lumley and a Dr. Richard Caldwell in 1582, consisted in pronouncing lectures for a period of seven years, with the purpose of "spreading light" and increasing the general knowledge of anatomy throughout England.

Harvey began his lectures in April 1616. At this time, at the age of thirty-seven, he was described as "a man of lowest stature, round faced; his eyes small, round, very black and full of spirit; his hair as black as a raven and curling". The notes which he used at the time are preserved in the British Museum.

At the beginning of his lectures, Harvey laid down the canons for his guidance:

1. "To show as much as may be at a glance, the whole belly for instance, and afterwards to subdivide the parts according to their positions and relations.
2. To point out what is peculiar to the actual body which is being dissected.
3. To supply only by speech what cannot be shown on your own credit and by authority.
4. To cut up as much as may be in the sight of the audience.
5. To enforce the right opinion by remarks drawn far and near, and to illustrate man by the structure of animals.
6. Not to praise or dispraise other anatomists, for all did well, and there was some excuse even for those who are in error.
7. Not to dispute with others, or attempt to confute them, except by the most obvious retort.
8. To state things briefly and plainly, yet not letting anything pass unmentioned which can be seen.
9. Not to speak of anything which can be as well explained without the body or can be read at home.
10. Not to enter into too much detail, or in too minute dissection, for the time does not permit.
11. To serve three courses according to the glass [i.e. allot a definite time to each part of the body]. In the first day's lectures the abdomen, nasty yet recompensed by its infinite variety. In the second the parlour, [i.e. the thorax?]. In the third day's lecture the divine banquet of the brain."

Physician to James I

Harvey continued to participate in the Lumleian lectures while also taking care of his patients at St Bartholomew's Hospital; he thus soon attained an important and fairly lucrative practice, which climaxed with his appointment as 'Physician Extraordinary' to King James I on 3 February 1618. He seems to have similarly served various aristocrats, including Lord Chancellor Bacon.

In 1628 he published in Frankfurt his completed treatise on the circulation of the blood, the De Motu Cordis. As a result of negative comments by other physicians Harvey "fell mightily in his practice", but continued advancing his career. He was re-elected 'Censor' of the College of Physicians in 1629, having been elected for the first time in 1613 and the second time in 1625. Eventually, Harvey was also elected Treasurer of the College.

Witchcraft trials

Harvey was a prominent sceptic regarding allegations of witchcraft. He was one of the examiners of four women from Lancashire accused of witchcraft in 1634, and as a consequence of his report, all of them were acquitted. Earlier, in 1632, while travelling with the King to Newmarket, he had been sent to investigate a woman accused of being a witch. Initially he told her that he was a wizard and had come to discuss the Craft with her, and asked whether she had a familiar. She put down a saucer of milk and called to a toad which came out and drank the milk. He then sent her out to fetch some ale, and killed the toad and dissected it, concluding that it was a perfectly ordinary animal and not supernatural in any way. When the woman returned she was naturally very angry and upset, but Harvey eventually silenced her by stating that he was the King's Physician, sent to discover whether she were a witch, and if she were, to have her apprehended.

Excursions abroad, election as physician to Charles I and the English Civil War

At the age of fifty-two, Harvey received commands by the king to accompany the Duke of Lennox during his trip abroad. This voyage – the first after his return from Padua – lasted three years, taking Harvey through the countries of France and Spain during the Mantuan War and Plague. During this journey he wrote to Viscount Dorchester:

"I can complain that by the way we could scarce see a dog, crow, kite, raven or any other bird, or anything to anatomize, only some few miserable people, the relics of the war and the plague where famine had made anatomies before I came. It is scarce credible in so rich, populous, and plentiful countries as these were that so much misery and desolation, poverty and famine should in so short a time be, as we have seen. I interpret it well that it will be a great motive for all here to have and procure assurance of settled peace. It is time to leave fighting when there is nothing to eat, nothing to be kept, and nothing to be gotten".

Having returned to England in 1632, Harvey accompanied King Charles I wherever he went as 'Physician in Ordinary.' In particular, Charles' hunting expeditions gave Harvey access to many deer carcasses; it was upon them that Harvey made many observations and consequent theories. Harvey returned to Italy in 1636, dining at the English College, Rome, as a guest of the Jesuits there, in October 1636. It is possible he met Galileo in Florence en route.

During the English Civil War a mob of citizen-soldiers against the King entered Harvey's lodgings, stole his goods, and scattered his papers. The papers consisted of "the records of a large number of dissections... of diseased bodies, with this observations on the development on insects, and a series of notes on comparative anatomy." During this period, Harvey maintained his position, helped the wounded on several occasions and protected the King's children during the Battle of Edgehill.

The conflicts of the Civil War soon led King Charles to Oxford, with Harvey attending, where the physician was made 'Doctor of Physic' in 1642 and later Warden of Merton College in 1645. "In Oxford he (Harvey) very soon settled down to his accustomed pursuits, unmindful of the clatter of arms and of the constant marching and countermarching around him, for the city remained the base of operations until its surrender... "

Harvey's later years, death and burial

The surrender of Oxford in 1645 marks the beginning of Harvey's gradual retirement from public life and duties. Now sixty-eight years old and childless, Harvey had lost three brothers and his wife by this time. He thus decided to return to London, and lived with his brothers Eliab and Daniel at different periods. Having retired from St Bartholomew's Hospital and his various other aforementioned positions, he passed most of this time reading general literature. Several attempts to bring Harvey back into the 'working world' were made, however; here is an excerpt of one of Harvey's answers:

"Would you be the man who should recommend me to quit the peaceful haven where I now pass my life and launch again upon the faithless sea? You know full well what a storm my former lucubrations raised. Much better is it oftentimes to grow wise at home and in private, than by publishing what you have amassed with infinite labour, to stir up tempests that may rob you of peace and quiet for the rest of your days."

Harvey died at Roehampton in the house of his brother Eliab on 3 June 1657. Descriptions of the event seem to show that he died of a cerebral hemorrhage from vessels long injured by gout: it is highly probable that the left middle cerebral artery malfunctioned, leading to a gradual accumulation of blood to the brain which eventually overwhelmed it. There exists a fairly detailed account of what happened on that day; according to the information at hand, Harvey:

"went to speak and found that he had the dead palsy in his tongue; then he saw what was to become of him. He knew there were then no hopes of his recovery, so presently he sends for his young nephews to come up to him. He then made signs (for seized with the dead palsy in his tongue he could not speak) to let him blood his tongue, which did him little or no good, and so ended his days, dying in the evening of the day on which he was stricken, the palsy giving him an easy passport."

His will distributed his material goods and wealth throughout his extended family and also left a substantial amount of money to the College of Physicians.

Harvey was buried in Hempstead, Essex. The funeral procession started on 26 June 1657 leading Harvey to be placed in the 'Harvey Chapel' built by Eliab. The conditions of Harvey's burial are also known: "Harvey was laid in the chapel between the bodies of his two nieces, and like them he was lapt in lead, coffin less ". On St. Luke's Day, 18 October 1883, Harvey's remains were reinterred, the leaden case carried from the vault by eight Fellows of the College of Physicians, and deposited in a sarcophagus containing his works and an inscription:

"The body of William Harvey lapt in lead, simply soldered, was laid without shell or enclosure of any kind in the Harvey vault of this Church of Hempstead, Essex, in June 1657. In the course of time the lead enclosing the remains was, from expose and natural decay, so seriously damaged as to endanger its preservation, rendering some repair of it the duty of those interested in the memory of the illustrious discoverer of the circulation of the Blood. The Royal College of Physicians, of which corporate body Harvey was a munificent Benefactor did in the years 1882–1883, by permission of the Representatives of the Harvey family, undertake this duty. In accordance with this determination the leaden mortuary chest containing the remains of Harvey was repaired, and was, as far as possible, restored to its original state... "

"De Motu Cordis" (otherwise known as "On the Motion of the Heart and Blood")

Main article: Exercitatio Anatomica de Motu Cordis et Sanguinis in Animalibus

An experiment from Harvey's de Motu Cordis

Published in 1628 in the city of Frankfurt (host to an annual book fair that Harvey knew would allow immediate dispersion of his work), 72 page Exercitatio Anatomica de Motu Cordis et Sanguinis in Animalibus contains the matured account of the circulation of the blood. Opening with a simple but clear dedication to King Charles I, the quarto has 17 chapters which give a perfectly clear and connected account of the action of the heart and the consequent movement of the blood around the body in a circuit. Having only a tiny lens at his disposal, Harvey was not able to reach the adequate pictures that were attained through such microscopes used by Leeuwenhoek; thus he had to resort to theory – and not practical evidence – in certain parts of his book. After the first chapter, which simply outlines past ideas and accepted rules regarding the heart and lungs, Harvey moves on to a fundamental premise to his treatise, stating that it was extremely important to study the heart when it was active in order to truly comprehend its true movement; a task which even he found of great difficulty, as he says:

"...I found the task so truly arduous... that I was almost tempted to think... that the movement of the heart was only to be comprehended by God. For I could neither rightly perceive at first when the systole and when the diastole took place by reason of the rapidity of the movement..."

This initial thought led Harvey's ambition and assiduousness to a detailed analysis of the overall structure of the heart (studied with less hindrances in cold-blooded animals). After this, Harvey goes on to an analysis of the arteries, showing how their pulsation depends upon the contraction of the left ventricle, while the contraction of the right ventricle propels its charge of blood into the pulmonary artery. Whilst doing this, the physician reiterates the fact that these two ventricles move together almost simultaneously and not independently as had been thought previously by his predecessors. This discovery was made while observing the heart of such animals as the eel and several other types of fish; indeed, the general study of countless animals was of utmost importance to the physician: among the ones already cited, one can add the study of the snail, the invisible shrimp, the chick before its hatching and even the pigeon. A digression to an experiment can be made to this note: using the inactive heart of a dead pigeon and placing upon it a finger wet with saliva, Harvey was able to witness a transitory and yet incontrovertible pulsation. He had just witnessed the heart's ability to recover from fatigue.

As early as the 17th century, William Harvey had already discerned the existence of the Ductus Arteriosus and explained its relative function. Here he says, "...in embryos, whilst the lungs are in a state of inaction, performing no function, subject to no movement any more than if they had not been present, Nature uses the two ventricles of the heart as if they formed but one for the transmission of the blood." However, the apex of Harvey's work is probably the eighth chapter, in which he deals with the actual quantity of blood passing through the heart from the veins to the arteries. Coming into conflict with Galen's accepted view of the liver as the origin of venous blood, Harvey estimated the capacity of the heart, how much blood is expelled through each pump of the heart, and the number of times the heart beats in a half an hour. All of these estimates were purposefully low, so that people could see the vast amount of blood Galen's theory required the liver to produce. He estimated that the capacity of the heart was 1.5 imperial fluid ounces (43 ml), and that every time the heart pumps, 1/8 of that blood is expelled. This led to Harvey's estimate that about 1⁄6 imperial fluid ounce (4.7 ml) of blood went through the heart every time it pumped. The next estimate he used was that the heart beats 1000 times every half an hour, which gave 10 pounds 6 ounces of blood in a half an hour, and when this number was multiplied by 48 half hours in a day he realized that the liver would have to produce 540 pounds of blood in a day.

Having this simple but essential mathematical proportion at hand – which proved the overall impossible aforementioned role of the liver – Harvey went on to prove how the blood circulated in a circle by means of countless experiments initially done on serpents and fish: tying their veins and arteries in separate periods of time, Harvey noticed the modifications which occurred; indeed, as he tied the veins, the heart would become empty, while as he did the same to the arteries, the organ would swell up.

Image of veins from Harvey's Exercitatio Anatomica de Motu Cordis et Sanguinis in Animalibus

This process was later performed on the human body (in the image on the right): the physician tied a tight ligature onto the upper arm of a person. This would cut off blood flow from the arteries and the veins. When this was done, the arm below the ligature was cool and pale, while above the ligature it was warm and swollen. The ligature was loosened slightly, which allowed blood from the arteries to come into the arm, since arteries are deeper in the flesh than the veins. When this was done, the opposite effect was seen in the lower arm. It was now warm and swollen. The veins were also more visible, since now they were full of blood. Harvey then noticed little bumps in the veins, which he realized were the valves of the veins, discovered by his teacher, Hieronymus Fabricius. Harvey tried to push blood in the vein down the arm, but to no avail. When he tried to push it up the arm, it moved quite easily. The same effect was seen in other veins of the body, except the veins in the neck. Those veins were different from the others – they did not allow blood to flow up, but only down. This led Harvey to believe that the veins allowed blood to flow to the heart, and the valves maintained the one way flow.

Contrary to a popular misconception, Harvey did not predict the existence of capillaries. His observations convinced him that direct connection between veins and arteries are unnecessary; he wrote "blood permeates the pores" in the flesh and it is "absorbed and imbibed from every part" by the veins.

Views of the circulation of blood before Harvey

At the time of Harvey's publication, Galen had been an influential medical authority for several centuries. Galen believed that blood passed between the ventricles by means of invisible pores. According to Galen's views, the venous system was quite separate from the arterial system, except when they came in contact through the unseen pores. Arabic scholar Ibn al-Nafis had disputed aspects of Galen's views, providing a model that seems to imply a form of pulmonary circulation in his Commentary on Anatomy in Avicenna's Canon (1242). Al-Nafis stated that blood moved from the heart to the lungs, where it mixed with air, and then back to the heart, from which it spread to the rest of the body. Harvey's discoveries inevitably and historically came into conflict with Galen's teachings and the publication of his treatise De Motu Cordis incited considerable controversy within the medical community. Some doctors affirmed they would "rather err with Galen than proclaim the truth with Harvey." Galen incompletely perceived the function of the heart, believing it a "productor of heat", while the function of its affluents, the arteries, was that of cooling the blood as the lungs "...fanned and cooled the heart itself". Galen thought that during dilation the arteries sucked in air, while during their contraction they discharged vapours through pores in the flesh and skin.

Until the 17th century, two separate systems were thought to be involved in blood circulation: the natural system, containing venous blood which had its origin in the liver, and the vital system, containing arterial blood and the 'spirits' which flowed from the heart, distributing heat and life to all parts. Like bellows, the lungs fanned and cooled this vital blood.

Independently of Ibn Al-Nafis, Michael Servetus identified pulmonary circulation, but this discovery did not reach the public because it was written down for the first time in the Manuscript of Paris in 1546. It was later published in the theological work which caused his execution in 1553, almost all copies of which were destroyed. In: Christianismi Restitutio, Book V, the Aragonese Miguel Servet (Michel de Villeneuve, 1509?–1553) wrote: 'The blood is passed through the pulmonary artery to the pulmonary vein for a lengthy pass through the lungs, during which it becomes red, and gets rid of the sooty fumes by the act of exhalation'.

Pulmonary circulation was described by Renaldus Columbus, Andrea Cesalpino and Vesalius, before Harvey would provide a refined and complete description of the circulatory system.

On Animal Generation

Harvey's other major work was Exercitationes de generatione animalium, published in 1651. He had been working on it for many years but might never have finished it without the encouragement of his friend George Ent.

The book starts with a description of development of the hen's egg. The major part is theoretical, dealing with Aristotle's theories and the work of the physicians following Galen and up to Fabricius. Finally he deals with embryogenesis in viviparous animals especially hinds and does. The treatment is generally Aristotelian and limited by use of a simple magnifying lens.

Needham claims the following achievements for this work.

• His doctrine of omne vivum ex ovo (all life comes from the egg) was the first definite statement against the idea of spontaneous generation. He denied the possibility of generation from excrement and from mud, and pointed out that even worms have eggs.
• He identified the citricula as the point in the yolk from which the embryo develops and the blastoderm surrounding the embryo.
• He destroyed once and for all the Aristotelian (semen-blood) and Epicurean (semen-semen) theories of early embryogeny.
• He settled the long controversy about which parts of the egg were nutritive and which was formative, by demonstrating the unreality of the distinction.

Impact on medical practice

A final allusion to the rules established and followed by the physician throughout his life can be made:

1. "That none be taken into the Hospital but such as be curable, or but a certain number of such as are curable.
2. That none lurk here for relief only or for slight causes.
3. That the Chirurgions, in all difficult cases or where inward physic may be necessary, shall consult with the Doctor, at the times he sitteth once in the week and then the Surgeon himself relate to the Doctor what he conceiveth of the cure and what he hath done therein.
4. That no Chirurgion or his man do trepan the head, pierce the body, dismember, or do any great operation on the body of any but with the approbation and the direction of the Doctor..."

Arthur Schlesinger Jr. included William Harvey in a list of "The Ten Most Influential People of the Second Millennium" in the World Almanac & Book of Facts.

The main lecture theatre of the School of Clinical Medicine, University of Cambridge is named after William Harvey, who was an alumnus of the institute.

Personality

In terms of his personality, information shows that William Harvey was seen as a "...humorous but extremely precise man...", how he was often so immersed in his own thoughts that he would often suffer from insomnia (cured with a simple walk through the house), and how he was always ready for an open and direct conversation. He also loved the darkness, for it is said that it was there where "...he could best contemplate", thus sometimes hiding out in caves. A heavy drinker of coffee, Harvey would walk out combing his hair every morning full of energy and enthusiastic spirit through the fields. We have also come to understand Harvey's somewhat unorthodox method of dealing with his gout, here cited completely: "...his [Harvey's] cure was thus: he would sit with his legs bare...put them into a pail of water till he was almost dead with cold, then betake himself to his stove, and so 'twas gone". Apart from the already mentioned love of literature, Harvey was also an intense and dedicated observer of birds during his free time: several long and detailed passages of citations could be written delineating his observations in such places as the "Pile of Boulders" (a small island in Lancashire) and 'Bass Rock' (island off the East Coast of Scotland).

Gallery

• 
  William Harvey
• 
  Color Portrait
• 
  William Harvey, after a painting by Cornelius Jansen
• 
  William Harvey
• 
  1957 William Harvey Soviet Union postage stamp

See also

• Miguel Servet
• Amato Lusitano – Portuguese 16th century physician, also credited with the discovery of the circulation of the blood
• Josephus Struthius
• Scientific revolution
• List of multiple discoveries

Works

• Harvey, William (1889). On the Motion of the Heart and Blood in Animals. London: George Bell and Sons.
• Harvey, William; Franklin, Kenneth J. (translator); Wear, Andrew (introduction) (1993). The Circulation of the Blood and Other Writings. London: Everyman: Orion Publishing Group. ISBN 0-460-87362-8. {{cite book}}: |author2= has generic name (help)
• The Works of William Harvey. Robert Willis (translator). London: Sydenham Society. 1847.{{cite book}}: CS1 maint: others (link) Includes:
  • An anatomical disquisition on the motion of the heart and blood in animals
  • 2 disquisitions addressed to John Riolan, including refutations to objections to the circulation of the blood
  • Anatomical exercises on the generation of animals. To which are added:
    • On Paturition
    • On the uterine membranes and humours
    • On conception
  • Anatomical examination of the body of Thomas Parr
  • Letters

Further reading

• Butterfield, Herbert (1957). The Origins of Modern Science (revised ed.). New York: The Free Press.
• Power, D'Arcy (1897). William Harvey: Masters of Medicine. T. Fisher Unwin. ISBN 978-1-4179-6578-6.
• Gregory, Andrew (2001). Harvey's Heart, The Discovery of Blood Circulation. Cambridge, England: Icon Books.
• Harris, Paul (2007). William Harvey, Folkestone's Most Famous Son. Folkestone: Lilburne Press.
• Kearney, Hugh (1971). Science and Change 1500 – 1700. New York: McGraw-Hill.
• Mitchell, Silas Weir (1907). Some Memoranda in Regard to William Harvey, M.D.
• Munk, William (1878). The Roll of the Royal College of Physicians of London, Vol. I (2nd ed.). London. pp. 124–146.{{cite book}}: CS1 maint: location missing publisher (link)
• Rapson, Helen (1982). The Circulation of the Blood. London: Frederick Muller.
• Singer, Charles (1959). A History of Biology (third, revised ed.). London: Abelard-Schuman.
• Wright, Thomas (2012). Circulation: William Harvey's Revolutionnary Idea. London: Chatto.
• Royal Society of Medicine (Great Britain) (1913). Portraits of Dr. William Harvey. London: Humphrey Milford, Oxford University Press.

External links

• William Harvey info from the (US) National Health Museum
• The Harvey Genealogist: The Harvey Book: PART ONE (mentions William Harvey and various ancestors and relatives)
• William Harvey: "On The Motion Of The Heart And Blood In Animals", 1628
• Images from De motu cordis From The College of Physicians of Philadelphia Digital Library