Wyoming Highway 290 begins its western end at Park CR 4IX (Pitchfork Road) and Park CR 5XS, approximately 11 miles west of Meeteetse, near the Marathon Pitchfork oil fields. Highway 290 travels eastward along the south bank of the Greybull River which it will roughly parallel for its entire routing. WYO 290 passes north of the Lower Sunshine Reservoir and then crosses Wood River at just over 5 miles. As WYO 290 nears Meeteetse, it turns to travel more northeasterly and enters the town from the south. At 11.23 miles, it reaches its eastern terminus at Wyoming Highway 120 in Meeteetse.