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XLS or xls may refer to:
- Microsoft Excel file format, a spreadsheet file format
- Cadillac XLS, a prototype Cadillac concept car
- Exelis Inc. (NYSE symbol), a global aerospace, defense, information and services company
- Lusitanian language (ISO 639-3 code), an Indo-European Paleohispanic language
- Midwest Questar XLS, an American ultralight aircraft design
- Saint-Louis Airport (IATA airport code), near Saint-Louis, Senegal
| disambiguation page lists articles associated with the title XLS.
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