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XPF may refer to:

  • CFP franc, the currency used in the French overseas collectivities (collectivités d’outre-mer, or COM) of French Polynesia, New Caledonia and Wallis and Futuna
  • ERCC4, an enzyme that in humans is encoded by the ERCC4 gene
  • X Prize Foundation; offers inducement prize contests to encourage spaceflight and other technological development
  • a LMMS Preset File