Z100 may refer to:
Radio, in the United States of America
- KKRZ-FM 100.3 in Portland, Oregon
- KZOQ-FM 100.1 in Missoula, Montana
- KZRO-FM 100.1 in Mount Shasta, California, a station also known as “The Z-Channel”
- WBIZ-FM 100.7 in Eau Claire, Wisconsin
- WDZN-FM 99.5 in Midland/Cumberland, Maryland
- WHTZ-FM 100.3 in Newark (New Jersey) and New York City
- Z100 Internet, an Internet-only radio station from Buffalo, New York.
- Z100, the former moniker for KLRZ 100.3 in New Orleans, Louisiana
- Z100, the moniker for the defunct WKSZ in Philadelphia, Pennsylvania, whose frequency was succeeded by Y100 and is now occupied by Old School 100.3 WRNB.
- Z100, the former moniker for WRFX in the Charlotte, North Carolina market
- Zenith Z-100, an early microcomputer made by Zenith Data Systems
- Sendo Z100, a Sendo mobile phone model
- Current train number of Shanghai-Kowloon Through Train
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