ZIC1
Template:PBB ZIC1 is a member of the Zinc finger of the cerebellum (ZIC) protein family.[1][2]
ZIC1 is classified as a ZIC protein due to conservation of the five C2H2 zinc fingers, which enables the protein to interact with DNA and proteins. ZIC1 is found in close genomic configuration in another member of this protein family, ZIC4. Correct function of these proteins in critical for early development, and as such mutations of the genes encoding these proteins is known to result in various congenital defects. For example, if function of both ZIC1 and ZIC4 is lost (which can occur via an interstitial deletion due to their adjacent location) then this may result in the Dandy-Walker malformation.[3]
Interactions
ZIC1 has been shown to interact with GLI1[4] and GLI3.[4]
References
- ^ Ali RG, Bellchambers HM, Arkell RM (November 2012). "Zinc finger of the cerebellum (Zic): Transcription factors and co-factors". Int J Biochem Cell Bio. 22 (11): 2065–8. doi:10.1016/j.biocel.2012.08.012. PMID 22964024.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ "Entrez Gene: ZIC1 Zic family member 1 (odd-paired homolog, Drosophila)".
- ^ Grinberg I, Northrup H, Ardinger H, Prasad C, Dobyns WB, Millen KJ (October 2004). "Heterozygous deletion of the linked genes ZIC1 and ZIC4 is involved in Dandy-Walker malformation". Nat Genet. 36 (10): 1053–5. doi:10.1038/ng1420. PMID 15338008.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ a b Koyabu, Y; Nakata K; Mizugishi K; Aruga J; Mikoshiba K (March 2001). "Physical and functional interactions between Zic and Gli proteins". J. Biol. Chem. 276 (10). United States: 6889–92. doi:10.1074/jbc.C000773200. ISSN 0021-9258. PMID 11238441.
{{cite journal}}: Cite has empty unknown parameters:|laydate=,|laysource=, and|laysummary=(help)CS1 maint: unflagged free DOI (link)
Further reading
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