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Zeuterin (zū-tur-in) is the trade name of an injectable product containing zinc gluconate and the amino acid arginine, which is used for sterilizing young male dogs without the removal of the testicles.[1] The product is injected directly into the testicle,[2] where the zinc gluconate destroys the sperm and causes inflammation, which leads to fibrosis and causes sterility.[3] Sperm production continues for up to 60 days after product administration, and in some dogs does not stop completely,[4] although the product is 99.6% effective when given to dogs aged three to ten months of age.[5] Following administration, the testicles atrophy; the degree of atrophy may vary noticeably between testicles.[2] The male hormone, testosterone, is produced in limited quantities following treatment with Zeuterin, but after two years, testosterone production is similar to that in untreated dogs.[1] The continuing presence of testosterone means that, unlike surgical castration, chemical castration does not remove the risk of testosterone-associated disease, such as prostatic disease.[2]

This method of chemical castration is contraindicated in cases of undescended testicles (cryptorchidism), or if there is scrotal dermatitis or testicular disease.[2] If the product is not injected correctly, scrotal ulceration and swelling may occur.[1] The manufactuer, Ark Sciences, certifies veterinarians to use Zeuterin after they have completed a five-hour course regarding the correct location and manner to inject the drug.[6]

In the United States, this product was approved by the Food and Drug Administration (FDA) in 2003, under the trade name Neutersol, and was marketed from 2003 to 2005 by Pet Healthcare International.[3] In 2005, Pet Healthcare International severed ties with its manufacturing partner Addison Biologicals, and production of the drug stopped.[7] Ark Sciences acquired the intellectual property to Neutersol, rebranded it as Zeuterin,[8] and relaunched it in 2014.[9] In 2016, Ark Sciences suspended distribution of Zeuterin.[9]

Outside of the United States Zeuterin is known by the trade name Esterilsol.[1]


  1. ^ a b c d Macpherson, CNL; Meslin, F-X; Wandeler, AI, eds. (2012). "Chemosterilants". Dogs, zoonoses and public health (2nd ed.). Wallingford, Oxfordshire: CABI. p. 265. ISBN 9781845938352. 
  2. ^ a b c d Romich, Janet Amundson (2005). "Male hormone-like drugs". Fundamentals of pharmacology for veterinary technicians. Clifton Park, NY: Thomson Delmar Learning. pp. 162–4. ISBN 9781401842932. 
  3. ^ a b "Zeuterin/Esterilsol: Product profile and position paper" (PDF). Alliance for Contraception in Cats & Dogs. June 2015. Retrieved 2017-05-20. 
  4. ^ Tobias, KM; Johnston, Spencer A. (2011). "Nonsurgical sterilization techniques". Veterinary Surgery. London: Elsevier Health Sciences. p. 1910. ISBN 9780323263375. 
  5. ^ Tobias, KM (2011). "Chapter 29: Canine Castration - Chemical castration". Manual of Small Animal Soft Tissue Surgery. John Wiley & Sons. ISBN 9781119949541. 
  6. ^ Quenqua, Douglas (2 December 2013). "New Strides in Spaying and Neutering". The New York Times Company. Retrieved 2017-05-20. 
  7. ^ "Neutersol and Esterilsol: Injectable Sterilization for Male Dogs". Retrieved 3 January 2010. 
  8. ^ "Ark Sciences Releases Canine Sterilization Drug". Veterinary Practice News. 18 February 2014. Retrieved 2017-05-20. 
  9. ^ a b Lau, Edie (22 April 2016). "Zeuterin marketer falters two years after U.S. debut - VIN". The VIN News Service. Retrieved 2017-05-20.