UK-414,495

UK-414,495
Identifiers
	IUPAC name (2R)-2-({1-[(5-ethyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl}methyl)pentanoic acid;
CAS Number	337962-93-3 ;
PubChem CID	9949799;
ChemSpider	8125410 ;
UNII	JV29CG9MQ2;
ChEMBL	ChEMBL378763 ;
CompTox Dashboard (EPA)	DTXSID10432050 ;
Chemical and physical data
Formula	C16H25N3O3S
Molar mass	339.45 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCC[C@H](CC1(CCCC1)C(=O)NC2=NN=C(S2)CC)C(=O)O;
	InChI InChI=1S/C16H25N3O3S/c1-3-7-11(13(20)21)10-16(8-5-6-9-16)14(22)17-15-19-18-12(4-2)23-15/h11H,3-10H2,1-2H3,(H,20,21)(H,17,19,22)/t11-/m1/s1 ; Key:FWXXCSISWQQOGS-LLVKDONJSA-N ;
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UK-414,495 is a drug developed by Pfizer for the treatment of female sexual arousal disorder. UK-414,495 acts as a potent, selective inhibitor of the enzyme neutral endopeptidase, which normally serves to break down the neuropeptide VIP. The consequent increase in VIP activity alters blood flow to the genital region leading to increased lubrication and muscle relaxation.^[1]^[2]^[3]

References

^ Armer R, Warne P, Witherington J (2006). "Recent disclosures of clinical drug candidates". Drug News & Perspectives. 19 (1): 65–72. PMID 16550257.
^ Angulo J (May 2010). "Neutral endopeptidase inhibition: could it have a role in the treatment of female sexual arousal disorder?". British Journal of Pharmacology. 160 (1): 48–50. doi:10.1111/j.1476-5381.2010.00693.x. PMC 2860205. PMID 20412067.
^ Wayman CP, Baxter D, Turner L, Van Der Graaf PH, Naylor AM (May 2010). "UK-414,495, a selective inhibitor of neutral endopeptidase, potentiates pelvic nerve-stimulated increases in female genital blood flow in the anaesthetized rabbit". British Journal of Pharmacology. 160 (1): 51–59. doi:10.1111/j.1476-5381.2010.00691.x. PMC 2860206. PMID 20412068.

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[pmid16550257-1] Armer R, Warne P, Witherington J (2006). "Recent disclosures of clinical drug candidates". Drug News & Perspectives. 19 (1): 65–72. PMID 16550257.

[2] Angulo J (May 2010). "Neutral endopeptidase inhibition: could it have a role in the treatment of female sexual arousal disorder?". British Journal of Pharmacology. 160 (1): 48–50. doi:10.1111/j.1476-5381.2010.00693.x. PMC 2860205. PMID 20412067.

[3] Wayman CP, Baxter D, Turner L, Van Der Graaf PH, Naylor AM (May 2010). "UK-414,495, a selective inhibitor of neutral endopeptidase, potentiates pelvic nerve-stimulated increases in female genital blood flow in the anaesthetized rabbit". British Journal of Pharmacology. 160 (1): 51–59. doi:10.1111/j.1476-5381.2010.00691.x. PMC 2860206. PMID 20412068.

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See also

References