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Petroleomics

From Wikipedia, the free encyclopedia
Petroleomics is the chemical characterization of petroleum such as this sample of North Sea crude oil.

Petroleomics is the identification of the totality of the constituents of naturally occurring petroleum and crude oil using high resolution mass spectrometry.[1][2][3] In addition to mass determination, petroleomic analysis sorts the chemical compounds into heteroatom class (nitrogen, oxygen and sulfur), type (degree of unsaturation, and carbon number).[4] The name is a combination of petroleum and -omics (collective chemical characterization and quantification).

History

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A gas chromatography-mass spectrometer at the National Bureau of Standards in 1948.

Mass spectrometry characterization of petroleum has been performed since the first commercial mass spectrometers were introduced in the 1940s.[5][6] Early mass spectrometry was limited to relatively low molecular weight nonpolar species accessed mainly by electron ionization with mass analysis with sector mass spectrometers. By the end of the 20th century, separations combined with mass spectrometric techniques such as gas chromatography-mass spectrometry and liquid chromatography mass spectrometry have characterizated petroleum distillates such as gasoline, diesel, and gas oil.[7]

The first petroleum analysis with electrospray ionization was demonstrated in 2000 by Zhan and Fenn, who studied the polar species in petroleum distillates with low-resolution MS.[8] Electrospray ionization was coupled with high-resolution FT-ICR by Marshall and coworkers.[1] To date, many studies on petroleomic analysis of crude oils have been published. Most work has been done by the group of Marshall at the National High Magnetic Field Laboratory (NHMFL) and Florida State University.[2]

Ionization methods

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A high resolution FTICR mass spectrometer is often used for petroleomics.

Ionization of nonpolar petroleum components can be achieved by field desorption ionization and atmospheric pressure photoionization (APPI).[9] field desorption FT-ICR MS has enabled the identification of a large number of nonpolar components in crude oils that are not accessible by electrospray, such as benzo- and dibenzothiophenes, furans, cycloalkanes, and polycyclic aromatic hydrocarbons (PAHs). A drawback of field desorption is that it is slow, mainly due to the need of ramping the current to the emitter in order to volatilize and ionize molecules. APPI can ionize both polar and nonpolar species,[10] and an APPI spectrum can be generated in just a few seconds. However, APPI ionizes a broad range of compound classes and produces both protonated and molecular ion peaks, resulting in a complex mass spectrum.[2]

Kendrick analysis

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Plot of Kendrick mass defect as function of Kendrick mass; horizontal lines indicate common repeat units. Each dot in the plot corresponds to a peak measured in a mass spectrum.

High mass resolution data analysis is usually undertaken by converting the mass spectra to the Kendrick mass scale, in which the mass of a methylene unit is set to exactly 14 (CH2 = 14.0000 instead of 14.01565 daltons).[11] This rescaling of the data aids in the identification of homologous series according to alkylation, class (number of heteroatoms), and type (double bond equivalent, DBE, also called rings plus double bonds or degree of unsaturation). The scaled data is then used to obtain the Kendrick mass defect (KMD), which is given by

where the nominal Kendrick is the Kendrick mass rounded to the nearest integer. Double bond equivalent (DBE) is calculated according to

where C = number of carbons, H = number of hydrogens, X= number of halogens and N = number of nitrogens.[12] O

Compounds with the same DBE have the same mass defect. Therefore, Kendrick normalization yields a set of series with identical mass defect that appear as horizontal rows in a plot of DBE versus Kendrick mass. The data can also be plotted as a 3D heat-map to indicate the relative intensity of the mass spectral peaks. From the Kendrick plot, the species with peaks in the mass spectrum can be sorted into compound classes by the number of nitrogen, oxygen and sulfur heteroatoms.

The data can also be represented with a Van Krevelen diagram.[13]

See also

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References

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  1. ^ a b Marshall, Alan G.; Rodgers, Ryan P. (2004). "Petroleomics: The Next Grand Challenge for Chemical Analysis". Accounts of Chemical Research. 37 (1): 53–59. doi:10.1021/ar020177t. ISSN 0001-4842. PMID 14730994.
  2. ^ a b c Marshall, A. G.; Rodgers, R. P. (2008). "Petroleomics: Chemistry of the underworld". Proceedings of the National Academy of Sciences. 105 (47): 18090–18095. Bibcode:2008PNAS..10518090M. doi:10.1073/pnas.0805069105. ISSN 0027-8424. PMC 2587575. PMID 18836082.
  3. ^ Cho, Yunju; Ahmed, Arif; Islam, Annana; Kim, Sunghwan (2014). "Developments in FT-ICR MS instrumentation, ionization techniques, and data interpretation methods for petroleomics". Mass Spectrometry Reviews. 34 (2): 248–263. Bibcode:2015MSRv...34..248C. doi:10.1002/mas.21438. ISSN 0277-7037. PMID 24942384.
  4. ^ Oliver C. Mullins; Eric Y. Sheu; Ahmed Hammami; Alan G. Marshall (8 November 2007). Asphaltenes, Heavy Oils, and Petroleomics. Springer. ISBN 978-0-387-68903-6.
  5. ^ Mynard Hamming (2 December 2012). Interpretation of Mass Spectra of Organic Compounds. Elsevier. pp. 3–. ISBN 978-0-323-14314-1.
  6. ^ Nadkarni, R. A. Kishore; Mendez, Aaron; Colin, Todd B. (2011). "Applications of Mass Spectrometry in the Petroleum and Petrochemical Industries". Spectroscopic Analysis of Petroleum Products and Lubricants: 287–287–62. doi:10.1520/MONO10113M. ISBN 978-0-8031-7020-9.
  7. ^ Rodgers, Ryan P.; McKenna, Amy M. (2011). "Petroleum Analysis". Analytical Chemistry. 83 (12): 4665–4687. doi:10.1021/ac201080e. ISSN 0003-2700. PMID 21528862.
  8. ^ Zhan, Dongliang; Fenn, John B (2000). "Electrospray mass spectrometry of fossil fuels". International Journal of Mass Spectrometry. 194 (2–3): 197–208. Bibcode:2000IJMSp.194..197Z. doi:10.1016/S1387-3806(99)00186-4. ISSN 1387-3806.
  9. ^ Hsu, Chang S.; Hendrickson, Christopher L.; Rodgers, Ryan P.; McKenna, Amy M.; Marshall, Alan G. (2011). "Petroleomics: advanced molecular probe for petroleum heavy ends". Journal of Mass Spectrometry. 46 (4): 337–343. Bibcode:2011JMSp...46..337H. doi:10.1002/jms.1893. ISSN 1076-5174. PMID 21438082.
  10. ^ Purcell, Jeremiah M.; Hendrickson, Christopher L.; Rodgers, Ryan P.; Marshall, Alan G. (2006). "Atmospheric Pressure Photoionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry for Complex Mixture Analysis". Analytical Chemistry. 78 (16): 5906–5912. doi:10.1021/ac060754h. ISSN 0003-2700. PMID 16906739.
  11. ^ Hughey, Christine A.; Hendrickson, Christopher L.; Rodgers, Ryan P.; Marshall, Alan G.; Qian, Kuangnan (2001). "Kendrick Mass Defect Spectrum: A Compact Visual Analysis for Ultrahigh-Resolution Broadband Mass Spectra". Analytical Chemistry. 73 (19): 4676–4681. doi:10.1021/ac010560w. ISSN 0003-2700. PMID 11605846.
  12. ^ "1". Organic Structural Spectroscopy. Pearson Prentice Hall. 2011. ISBN 978-0-321-59256-9.
  13. ^ Wu, Zhigang; Rodgers, Ryan P.; Marshall, Alan G. (2004). "Two- and Three-Dimensional van Krevelen Diagrams: A Graphical Analysis Complementary to the Kendrick Mass Plot for Sorting Elemental Compositions of Complex Organic Mixtures Based on Ultrahigh-Resolution Broadband Fourier Transform Ion Cyclotron Resonance Mass Measurements". Analytical Chemistry. 76 (9): 2511–2516. doi:10.1021/ac0355449. ISSN 0003-2700. PMID 15117191.
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