Recombinase
Recombinases are genetic recombination enzymes. DNA recombinases are widely used in multicellular organisms to manipulate the structure of genomes, and to control gene expression. These enzymes, derived from bacteria and fungi, catalyze directionally sensitive DNA exchange reactions between short (30–40 nucleotides) target site sequences that are specific to each recombinase. These reactions enable four basic functional modules, excision/insertion, inversion, translocation and cassette exchange, which have been used individually or combined in a wide range of configurations to control gene expression.[1][2][3][4]
Types include:
References
- ^ Aljoscha Nern, Barret D. Pfeiffer, Karel Svoboda, and Gerald M. Rubin (2011). "Multiple new site-specific recombinases for use in manipulating animal genomes". PNAS. 108 (34): 14198–14203. doi:10.1073/pnas.1111704108.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ García-Otín AL, Guillou F (2006) Mammalian genome targeting using site-specific recombinases. Front Biosci 11:1108–1136.
- ^ Dymecki SM, Kim JC (2007) Molecular neuroanatomy’s “Three Gs”: A primer. Neuron 54:17–34.
- ^ Luan H, White BH (2007) Combinatorial methods for refined neuronal gene targeting. Curr Opin Neurobiol 17:572–580.
External links
- Recombinases at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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