Tre recombinase

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Tre recombinase is an experimental enzyme that in lab tests has removed DNA inserted by HIV from infected cells.[1] The enzyme was derived from Cre recombinase through selective mutation for the purposes of identifying HIV markers, which are not bounded by loxP sites and therefore disallow attempts at Cre-Lox recombination.


  1. ^ Sarkar, Indrani; Hauber, Ilona; Hauber, Joachim; Buchholz, Frank (2007). "HIV-1 proviral DNA excision using an evolved recombinase". Science. 316 (5833): 1912–15. doi:10.1126/science.1141453. PMID 17600219. 

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