Glomeruloid hemangioma: Difference between revisions
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'''Glomeruloid hemangioma''' is a distinctive [[vascular tumor]] first described in 1990 when found to be associated with [[POEMS syndrome]] and [[Castleman disease]].<ref name=Andrew2020>{{cite book |last1=James |first1=William D. |last2=Elston |first2=Dirk |last3=Treat |first3=James R. |last4=Rosenbach |first4=Misha A. |last5=Neuhaus |first5=Isaac |title=Andrews' Diseases of the Skin: Clinical Dermatology |date=2020 |publisher=Elsevier |location=Edinburgh|isbn=978-0-323-54753-6 |page=594 |edition=13th |chapter-url=https://books.google.com/books?id=UEaEDwAAQBAJ&dq=Dermal&pg=PA594 |language=en |chapter=28. Dermal and subcutaneous tumors}}</ref><ref name="Bolognia">{{cite book |author=Rapini, Ronald P. |author2=Bolognia, Jean L. |author3=Jorizzo, Joseph L. |title=Dermatology: 2-Volume Set |publisher=Mosby |location=St. Louis |year=2007 |isbn=978-1-4160-2999-1 }}</ref> |
'''Glomeruloid hemangioma''' is a distinctive [[vascular tumor]] first described in 1990 when found to be associated with [[POEMS syndrome]] and [[Castleman disease]].<ref name=Andrew2020>{{cite book |last1=James |first1=William D. |last2=Elston |first2=Dirk |last3=Treat |first3=James R. |last4=Rosenbach |first4=Misha A. |last5=Neuhaus |first5=Isaac |title=Andrews' Diseases of the Skin: Clinical Dermatology |date=2020 |publisher=Elsevier |location=Edinburgh|isbn=978-0-323-54753-6 |page=594 |edition=13th |chapter-url=https://books.google.com/books?id=UEaEDwAAQBAJ&dq=Dermal&pg=PA594 |language=en |chapter=28. Dermal and subcutaneous tumors}}</ref><ref name="Bolognia">{{cite book |author=Rapini, Ronald P. |author2=Bolognia, Jean L. |author3=Jorizzo, Joseph L. |title=Dermatology: 2-Volume Set |publisher=Mosby |location=St. Louis |year=2007 |isbn=978-1-4160-2999-1 }}</ref> Glomeruloid hemangiomas can manifest as wine-red sessile or pedunculated [[Papule|papules]], papulonodules, subcutaneous bluish compressible tumors, or small, firm, reddish-violaceous, dome-shaped [[Papule|papules]]. |
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== Signs and symptoms == |
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Glomeruloid hemangiomas can manifest as wine-red sessile or pedunculated [[Papule|papules]], papulonodules, subcutaneous bluish compressible tumors, or small, firm, reddish-violaceous, dome-shaped [[Papule|papules]].<ref name="normal individuals">{{cite journal | last=Gupta | first=Jyoti | last2=Kandhari | first2=Rajat | last3=Ramesh | first3=V | last4=Singh | first4=Avninder | title=Glomeruloid hemangioma in normal individuals | journal=Indian Journal of Dermatology | publisher=Medknow | volume=58 | issue=2 | year=2013 | issn=0019-5154 | doi=10.4103/0019-5154.108088 | doi-access=free | page=160}}</ref> They mostly reside on the trunk and proximal limbs and range in size from a few millimeters to a few centimeters in diameter.<ref name="Cutaneous angiomas">{{cite journal | last=Puig | first=Lluis | last2=Moreno | first2=Abelardo | last3=Domingo | first3=Pere | last4=Llistosella | first4=Enric | last5=de Moragas | first5=José M. | title=Cutaneous angiomas in POEMS syndrome | journal=Journal of the American Academy of Dermatology | publisher=Elsevier BV | volume=12 | issue=5 | year=1985 | issn=0190-9622 | doi=10.1016/s0190-9622(85)70123-5 | pages=961–964}}</ref><ref name="cerebriform morphology">{{cite journal | last=Chan | first=P. T. | last2=Lee | first2=K. C. | last3=Chong | first3=L. Y. | last4=Lo | first4=K. K. | last5=Cheung | first5=Y. F. | title=Glomeruloid haemangioma with cerebriform morphology in a patient with POEMS syndrome | journal=Clinical and Experimental Dermatology | publisher=Oxford University Press (OUP) | volume=31 | issue=6 | year=2006 | issn=0307-6938 | doi=10.1111/j.1365-2230.2006.02213.x | pages=775–777}}</ref> There have also been rare reports of glomeruloid hemangioma impacting the face.<ref name="cutaneous marker">{{cite journal | last=Tsai | first=Chang‐Yu | last2=Lai | first2=Chan‐Ho | last3=Chan | first3=Heng‐Leong | last4=Kuo | first4=Tseng‐tong | title=Glomeruloid hemangioma –‐ a specific cutaneous marker of POEMS syndrome | journal=International Journal of Dermatology | publisher=Wiley | volume=40 | issue=6 | year=2001 | issn=0011-9059 | doi=10.1046/j.1365-4362.2001.01246-2.x | pages=403–406}}</ref><ref name="Multicentric Castleman's">{{cite journal | last=Yang | first=Seong Gyu | last2=Cho | first2=Kwang Hyun | last3=Bang | first3=Yung-Jue | last4=Kim | first4=Chul Woo | title=A Case of Glomeruloid Hemangioma Associated With Multicentric Castleman's Disease | journal=The American Journal of Dermatopathology | publisher=Ovid Technologies (Wolters Kluwer Health) | volume=20 | issue=3 | year=1998 | issn=0193-1091 | doi=10.1097/00000372-199806000-00008 | pages=266–270}}</ref> There have also been reports of eruptive angiomatous lesions, which resemble [[Eruptive histiocytoma|eruptive histiocytomas]].<ref name="Perniciaro 1995">{{cite journal | last=Perniciaro | first=Charles | title=POEMS syndrome | journal=Seminars in Dermatology | publisher=Elsevier BV | volume=14 | issue=2 | year=1995 | issn=0278-145X | doi=10.1016/s1085-5629(05)80013-6 | pages=162–165}}</ref> |
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== Causes == |
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Glomeruloid hemangiomas are most commonly associated with [[POEMS syndrome]], occurring in up to 45% of individuals with [[POEMS syndrome]].<ref name="Soft Tissue">{{cite book | last=Mocellin | first=Simone | title=Soft Tissue Tumors | chapter=Glomeruloid Hemangioma | publisher=Springer International Publishing | publication-place=Cham | date=2021 | isbn=978-3-030-58709-3 | doi=10.1007/978-3-030-58710-9_112 | page=377–378}}</ref> Glomeruloid hemangiomas have also been associated with [[TAFRO syndrome]].<ref name="TAFRO syndrome">{{cite journal | last=Shinozaki-Ushiku | first=Aya | last2=Higashihara | first2=Takaaki | last3=Ikemura | first3=Masako | last4=Sato | first4=Junichiro | last5=Nangaku | first5=Masaomi | last6=Ushiku | first6=Tetsuo | last7=Fukayama | first7=Masashi | title=Glomeruloid hemangioma associated with TAFRO syndrome | journal=Human Pathology | publisher=Elsevier BV | volume=82 | year=2018 | issn=0046-8177 | doi=10.1016/j.humpath.2018.04.011 | pages=172–176}}</ref> Rarely glomeruloid hemangiomas can occur in individuals with no systematic conditions.<ref name="Without Systemic">{{cite journal | last=Roy | first=Rita R | last2=Shimada | first2=Katsumitsu | last3=Hasegawa | first3=Hiromasa | title=A Case of Oral Glomeruloid Hemangioma Without Systemic Conditions | journal=Cureus | date=2022-01-29 | issn=2168-8184 | pmid=35145824 | pmc=8803383 | doi=10.7759/cureus.21705 | page=}}</ref> |
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== Diagnosis == |
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The histopathologic examination displays well-defined, dispersed dermal structures in different sizes that have resemblance to [[Glomerulus (kidney)|renal glomeruli]]. The central vessel is bigger and has a sinusoidal appearance, and it is surrounded by a network of small [[capillary]] vessels on the periphery.<ref name="Hernández 2017">{{cite journal | last=Hernández Aragüés | first=I. | last2=Pulido Pérez | first2=A. | last3=Ciudad Blanco | first3=C. | last4=Parra Blanco | first4=V. | last5=Suárez Fernández | first5=R. | title=Glomeruloid Hemangioma and POEMS Syndrome | journal=Actas Dermo-Sifiliográficas (English Edition) | publisher=Elsevier BV | volume=108 | issue=2 | year=2017 | issn=1578-2190 | doi=10.1016/j.adengl.2016.12.006 | pages=e15–e19}}</ref> |
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== See also == |
== See also == |
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* [[POEMS syndrome]] |
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* [[List of cutaneous conditions]] |
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* [[Hemangioma]] |
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== References == |
== References == |
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{{reflist}} |
{{reflist}} |
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== Further reading == |
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* {{cite journal | last=González-Guerra | first=E. | last2=Haro | first2=M. R. | last3=Fariña | first3=M. C. | last4=Martín | first4=L. | last5=Manzarbeitia | first5=L. | last6=Requena | first6=L. | title=Glomeruloid haemangioma is not always associated with POEMS syndrome | journal=Clinical and Experimental Dermatology | publisher=Oxford University Press (OUP) | volume=34 | issue=7 | year=2009 | issn=0307-6938 | doi=10.1111/j.1365-2230.2008.02997.x | pages=800–803 | ref=none}} |
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* {{cite journal | last=Phillips | first=Julie A. | last2=Dixon | first2=Julie E. | last3=Richardson | first3=Jeffrey B. | last4=Fabre | first4=Vilma C. | last5=Callen | first5=Jeffrey P. | title=Glomeruloid hemangioma leading to a diagnosis of POEMS syndrome | journal=Journal of the American Academy of Dermatology | publisher=Elsevier BV | volume=55 | issue=1 | year=2006 | issn=0190-9622 | doi=10.1016/j.jaad.2006.02.036 | pages=149–152 | ref=none}} |
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== External links == |
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* [https://dermnetnz.org/topics/glomeruloid-haemangioma-pathology DermNet] |
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* [https://www.visualdx.com/visualdx/diagnosis/glomeruloid+hemangioma?diagnosisId=55200&moduleId=101 VisualDx] |
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{{Medical resources |
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| ICD11 = {{ICD11|XH9NB0}} |
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| ICD10 = {{ICD10|D23.9}} |
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| SNOMED CT = 403976007 |
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{{Vascular tumors}} |
{{Vascular tumors}} |
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[[Category:Dermal and subcutaneous growths]] |
[[Category:Dermal and subcutaneous growths]] |
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{{Dermal-growth-stub}} |
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Revision as of 00:12, 28 April 2024
| Glomeruloid hemangioma | |
|---|---|
| Specialty | Dermatology |
Glomeruloid hemangioma is a distinctive vascular tumor first described in 1990 when found to be associated with POEMS syndrome and Castleman disease.[1][2] Glomeruloid hemangiomas can manifest as wine-red sessile or pedunculated papules, papulonodules, subcutaneous bluish compressible tumors, or small, firm, reddish-violaceous, dome-shaped papules.
Signs and symptoms
Glomeruloid hemangiomas can manifest as wine-red sessile or pedunculated papules, papulonodules, subcutaneous bluish compressible tumors, or small, firm, reddish-violaceous, dome-shaped papules.[3] They mostly reside on the trunk and proximal limbs and range in size from a few millimeters to a few centimeters in diameter.[4][5] There have also been rare reports of glomeruloid hemangioma impacting the face.[6][7] There have also been reports of eruptive angiomatous lesions, which resemble eruptive histiocytomas.[8]
Causes
Glomeruloid hemangiomas are most commonly associated with POEMS syndrome, occurring in up to 45% of individuals with POEMS syndrome.[9] Glomeruloid hemangiomas have also been associated with TAFRO syndrome.[10] Rarely glomeruloid hemangiomas can occur in individuals with no systematic conditions.[11]
Diagnosis
The histopathologic examination displays well-defined, dispersed dermal structures in different sizes that have resemblance to renal glomeruli. The central vessel is bigger and has a sinusoidal appearance, and it is surrounded by a network of small capillary vessels on the periphery.[12]
See also
References
- ^ James, William D.; Elston, Dirk; Treat, James R.; Rosenbach, Misha A.; Neuhaus, Isaac (2020). "28. Dermal and subcutaneous tumors". Andrews' Diseases of the Skin: Clinical Dermatology (13th ed.). Edinburgh: Elsevier. p. 594. ISBN 978-0-323-54753-6.
- ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
- ^ Gupta, Jyoti; Kandhari, Rajat; Ramesh, V; Singh, Avninder (2013). "Glomeruloid hemangioma in normal individuals". Indian Journal of Dermatology. 58 (2). Medknow: 160. doi:10.4103/0019-5154.108088. ISSN 0019-5154.
- ^ Puig, Lluis; Moreno, Abelardo; Domingo, Pere; Llistosella, Enric; de Moragas, José M. (1985). "Cutaneous angiomas in POEMS syndrome". Journal of the American Academy of Dermatology. 12 (5). Elsevier BV: 961–964. doi:10.1016/s0190-9622(85)70123-5. ISSN 0190-9622.
- ^ Chan, P. T.; Lee, K. C.; Chong, L. Y.; Lo, K. K.; Cheung, Y. F. (2006). "Glomeruloid haemangioma with cerebriform morphology in a patient with POEMS syndrome". Clinical and Experimental Dermatology. 31 (6). Oxford University Press (OUP): 775–777. doi:10.1111/j.1365-2230.2006.02213.x. ISSN 0307-6938.
- ^ Tsai, Chang‐Yu; Lai, Chan‐Ho; Chan, Heng‐Leong; Kuo, Tseng‐tong (2001). "Glomeruloid hemangioma –‐ a specific cutaneous marker of POEMS syndrome". International Journal of Dermatology. 40 (6). Wiley: 403–406. doi:10.1046/j.1365-4362.2001.01246-2.x. ISSN 0011-9059.
- ^ Yang, Seong Gyu; Cho, Kwang Hyun; Bang, Yung-Jue; Kim, Chul Woo (1998). "A Case of Glomeruloid Hemangioma Associated With Multicentric Castleman's Disease". The American Journal of Dermatopathology. 20 (3). Ovid Technologies (Wolters Kluwer Health): 266–270. doi:10.1097/00000372-199806000-00008. ISSN 0193-1091.
- ^ Perniciaro, Charles (1995). "POEMS syndrome". Seminars in Dermatology. 14 (2). Elsevier BV: 162–165. doi:10.1016/s1085-5629(05)80013-6. ISSN 0278-145X.
- ^ Mocellin, Simone (2021). "Glomeruloid Hemangioma". Soft Tissue Tumors. Cham: Springer International Publishing. p. 377–378. doi:10.1007/978-3-030-58710-9_112. ISBN 978-3-030-58709-3.
- ^ Shinozaki-Ushiku, Aya; Higashihara, Takaaki; Ikemura, Masako; Sato, Junichiro; Nangaku, Masaomi; Ushiku, Tetsuo; Fukayama, Masashi (2018). "Glomeruloid hemangioma associated with TAFRO syndrome". Human Pathology. 82. Elsevier BV: 172–176. doi:10.1016/j.humpath.2018.04.011. ISSN 0046-8177.
- ^ Roy, Rita R; Shimada, Katsumitsu; Hasegawa, Hiromasa (2022-01-29). "A Case of Oral Glomeruloid Hemangioma Without Systemic Conditions". Cureus. doi:10.7759/cureus.21705. ISSN 2168-8184. PMC 8803383. PMID 35145824.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Hernández Aragüés, I.; Pulido Pérez, A.; Ciudad Blanco, C.; Parra Blanco, V.; Suárez Fernández, R. (2017). "Glomeruloid Hemangioma and POEMS Syndrome". Actas Dermo-Sifiliográficas (English Edition). 108 (2). Elsevier BV: e15–e19. doi:10.1016/j.adengl.2016.12.006. ISSN 1578-2190.
Further reading
- González-Guerra, E.; Haro, M. R.; Fariña, M. C.; Martín, L.; Manzarbeitia, L.; Requena, L. (2009). "Glomeruloid haemangioma is not always associated with POEMS syndrome". Clinical and Experimental Dermatology. 34 (7). Oxford University Press (OUP): 800–803. doi:10.1111/j.1365-2230.2008.02997.x. ISSN 0307-6938.
- Phillips, Julie A.; Dixon, Julie E.; Richardson, Jeffrey B.; Fabre, Vilma C.; Callen, Jeffrey P. (2006). "Glomeruloid hemangioma leading to a diagnosis of POEMS syndrome". Journal of the American Academy of Dermatology. 55 (1). Elsevier BV: 149–152. doi:10.1016/j.jaad.2006.02.036. ISSN 0190-9622.