MSMB: Difference between revisions
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'''Beta-microseminoprotein''' is a [[protein]] that in humans is encoded by the ''MSMB'' [[gene]].<ref name="pmid1783399">{{cite journal | author = Ulvsback M, Spurr NK, Lundwall A | title = Assignment of the human gene for beta-microseminoprotein (MSMB) to chromosome 10 and demonstration of related genes in other vertebrates | journal = Genomics | volume = 11 | issue = 4 | pages = 920–4 | year = 1992 | month = Mar | pmid = 1783399 | pmc = | doi =10.1016/0888-7543(91)90015-7 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MSMB microseminoprotein, beta-| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4477| accessdate = }}</ref> |
'''Beta-microseminoprotein''' is a [[protein]] that in humans is encoded by the ''MSMB'' [[gene]].<ref name="pmid1783399">{{cite journal | author = Ulvsback M, Spurr NK, Lundwall A | title = Assignment of the human gene for beta-microseminoprotein (MSMB) to chromosome 10 and demonstration of related genes in other vertebrates | journal = Genomics | volume = 11 | issue = 4 | pages = 920–4 | year = 1992 | month = Mar | pmid = 1783399 | pmc = | doi =10.1016/0888-7543(91)90015-7 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MSMB microseminoprotein, beta-| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4477| accessdate = }}</ref> |
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== Function == |
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| ⚫ | Beta-microseminoprotein is a member of the immunoglobulin binding factor family. It is synthesized by the epithelial cells of the prostate gland and secreted into the seminal plasma. This protein has [[inhibin]]-like activity. It may have a role as an autocrine paracrine factor in uterine, breast and other female reproductive tissues. Two alternatively spliced transcript variants encoding different isoforms are described for this gene. The use of alternate polyadenylation sites has been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: MSMB microseminoprotein, beta-| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4477| accessdate = }}</ref> |
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== Clinical significance == |
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The expression of beta-microseminoprotein is found to be decreased in [[prostate cancer]]. Furthermore decreased expression of the protein caused by the rs10993994 allele is associated with an increased risk of developing protaste cancer. |
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| ⚫ | Finally Urinary MSMB was better than urinary [[prostate-specific antigen|PSA]] at differentiating men with prostate cancer at all [[Gleason Grading System|Gleason grades]].<ref name="Whitaker_2010">{{cite journal | author = Whitaker HC, Kote-Jarai Z, Ross-Adams H, Warren AY, Burge J, et al. | title = The rs10993994 Risk Allele for Prostate Cancer Results in Clinically Relevant Changes in Microseminoprotein-Beta Expression in Tissue and Urine | journal = PLoS ONE | year = 2010 | volume = 5 | issue = 10 | pages = e13363 | doi = 10.1371/journal.pone.0013363 }}</ref> |
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== References == |
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Revision as of 18:35, 14 October 2010
Template:PBB Beta-microseminoprotein is a protein that in humans is encoded by the MSMB gene.[1][2]
Function
Beta-microseminoprotein is a member of the immunoglobulin binding factor family. It is synthesized by the epithelial cells of the prostate gland and secreted into the seminal plasma. This protein has inhibin-like activity. It may have a role as an autocrine paracrine factor in uterine, breast and other female reproductive tissues. Two alternatively spliced transcript variants encoding different isoforms are described for this gene. The use of alternate polyadenylation sites has been found for this gene.[2]
Clinical significance
The expression of beta-microseminoprotein is found to be decreased in prostate cancer. Furthermore decreased expression of the protein caused by the rs10993994 allele is associated with an increased risk of developing protaste cancer. Finally Urinary MSMB was better than urinary PSA at differentiating men with prostate cancer at all Gleason grades.[3]
References
- ^ Ulvsback M, Spurr NK, Lundwall A (1992). "Assignment of the human gene for beta-microseminoprotein (MSMB) to chromosome 10 and demonstration of related genes in other vertebrates". Genomics. 11 (4): 920–4. doi:10.1016/0888-7543(91)90015-7. PMID 1783399.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ a b "Entrez Gene: MSMB microseminoprotein, beta-".
- ^ Whitaker HC, Kote-Jarai Z, Ross-Adams H, Warren AY, Burge J; et al. (2010). "The rs10993994 Risk Allele for Prostate Cancer Results in Clinically Relevant Changes in Microseminoprotein-Beta Expression in Tissue and Urine". PLoS ONE. 5 (10): e13363. doi:10.1371/journal.pone.0013363.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
Further reading
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