MiR-144: Difference between revisions
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==Function== |
==Function== |
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miR-144 functions in a cluster with [[mir-451 microRNA|miR-451]]. This [[locus]] regulates the expression of a number of genes whose products are involved in [[erythropoiesis]].<ref>{{cite journal|last=Rasmussen|first=KD|coauthors=Simmini, S, Abreu-Goodger, C, Bartonicek, N, Di Giacomo, M, Bilbao-Cortes, D, Horos, R, Von Lindern, M, Enright, AJ, O'Carroll, D|title=The miR-144/451 locus is required for erythroid homeostasis.|journal=The Journal of experimental medicine|date=2010 Jul 5|volume=207|issue=7|pages=1351-8|pmid=20513743}}</ref> |
miR-144 functions in a cluster with [[mir-451 microRNA|miR-451]]. This [[locus]] regulates the expression of a number of genes whose products are involved in [[erythropoiesis]].<ref>{{cite journal|last=Rasmussen|first=KD|coauthors=Simmini, S, Abreu-Goodger, C, Bartonicek, N, Di Giacomo, M, Bilbao-Cortes, D, Horos, R, Von Lindern, M, Enright, AJ, O'Carroll, D|title=The miR-144/451 locus is required for erythroid homeostasis.|journal=The Journal of experimental medicine|date=2010 Jul 5|volume=207|issue=7|pages=1351-8|pmid=20513743}}</ref> One of the identified targets of miR-144 is [[IRS1|insulin receptor substrate 1]].<ref>{{cite journal|last=Karolina|first=DS|coauthors=Armugam, A, Tavintharan, S, Wong, MT, Lim, SC, Sum, CF, Jeyaseelan, K|title=MicroRNA 144 Impairs Insulin Signaling by Inhibiting the Expression of Insulin Receptor Substrate 1 in Type 2 Diabetes Mellitus.|journal=PloS one|date=2011|volume=6|issue=8|pages=e22839|pmid=21829658}}</ref> |
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==Applications== |
==Applications== |
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Revision as of 10:25, 7 September 2011
| miR-144 | |
|---|---|
 Conserved secondary structure of miR-144 precursor microRNA | |
| Identifiers | |
| Symbol | miR-144 |
| Alt. Symbols | MIR144 |
| Rfam | RF00682 |
| miRBase | MI0000460 |
| miRBase family | MIPF0000093 |
| NCBI Gene | 406936 |
| HGNC | 31531 |
| OMIM | 612070 |
| RefSeq | NR_029685 |
| Other data | |
| RNA type | miRNA |
| Domain(s) | Mammalia |
| GO | 0035195 |
| SO | 0001244 |
| Locus | Chr. 17 q11.2 |
| PDB structures | PDBe |
miR-144 is a family of microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precusor hairpin by the enzyme Dicer.[1]
GATA4 is thought to activate transcription of the miR-144 microRNA precursor.[2]
Function
miR-144 functions in a cluster with miR-451. This locus regulates the expression of a number of genes whose products are involved in erythropoiesis.[3] One of the identified targets of miR-144 is insulin receptor substrate 1.[4]
Applications
miR-144 has been identified as one of a number of potential miRNA targets which could be used to treat schizophrenia and bipolar affective disorder.[5] It has also been suggested as a potential therapeutic tool to treat ischemic heart disease.[2]
References
- ^ Ambros, V (2001 Dec 28). "microRNAs: tiny regulators with great potential". Cell. 107 (7): 823–6. PMID 11779458.
{{cite journal}}: Check date values in:|date=(help) - ^ a b Zhang, X (2010 Nov). "Synergistic effects of the GATA-4-mediated miR-144/451 cluster in protection against simulated ischemia/reperfusion-induced cardiomyocyte death". Journal of molecular and cellular cardiology. 49 (5): 841–50. PMID 20708014.
{{cite journal}}: Check date values in:|date=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ Rasmussen, KD (2010 Jul 5). "The miR-144/451 locus is required for erythroid homeostasis". The Journal of experimental medicine. 207 (7): 1351–8. PMID 20513743.
{{cite journal}}: Check date values in:|date=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ Karolina, DS (2011). "MicroRNA 144 Impairs Insulin Signaling by Inhibiting the Expression of Insulin Receptor Substrate 1 in Type 2 Diabetes Mellitus". PloS one. 6 (8): e22839. PMID 21829658.
{{cite journal}}: Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ Dinan, TG (2010 Apr). "MicroRNAs as a target for novel antipsychotics: a systematic review of an emerging field". The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP). 13 (3): 395–404. PMID 19849891.
{{cite journal}}:|access-date=requires|url=(help); Check date values in:|date=(help)(subscription required)
Further reading
- Zhang, HY (2011 Apr 6). "MicroRNAs 144, 145, and 214 are down-regulated in primary neurons responding to sciatic nerve transection". Brain research. 1383: 62–70. PMID 21276775.
{{cite journal}}: Check date values in:|date=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help)