HEAT repeat: Difference between revisions

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	1b3u, 1f59, 1gcj, 1ibr, 1m5n, 1o6o, 1o6p, 1qbk, 1qgr, 1u6g, 1ukl, 2bku

HEAT repeat
HEAT repeat
	An example of an alpha solenoid structure composed of 15 HEAT repeats. The protein phosphatase 2A regulatory subunit is shown with the N-terminus in blue at bottom and the C-terminus in red at top. A single helix-turn-helix motif is shown in the center with the outer helix in pink, the inner helix in green, and the turn in white. From PDB: 2IAE.
Identifiers
Symbol	HEAT
Pfam	PF02985
InterPro	IPR000357
PROSITE	PDOC50077
SCOP2	1b3u / SCOPe / SUPFAM
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	1b3u, 1f59, 1gcj, 1ibr, 1m5n, 1o6o, 1o6p, 1qbk, 1qgr, 1u6g, 1ukl, 2bku

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Revision as of 04:24, 13 October 2016

A HEAT repeat is tandem repeat protein structural motif composed of two alpha helices linked by a short loop. HEAT repeats can form alpha solenoids, a type of solenoid protein domain found in a number of cytoplasmic proteins. The name "HEAT" is an acronym for four proteins in which this repeat structure is found: Huntingtin, elongation factor 3 (EF3), protein phosphatase 2A (PP2A), and the yeast kinase TOR1.^[3] HEAT repeats form extended superhelical structures which are often involved in intracellular transport; they are structurally related to armadillo repeats. The nuclear transport protein importin beta contains 19 HEAT repeats.

References

^ Cho, Uhn Soo; Xu, Wenqing (1 November 2006). "Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme". Nature. 445 (7123): 53–57. doi:10.1038/nature05351.
^ Groves MR, Hanlon N, Turowski P, Hemmings BA, Barford D (January 1999). "The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs". Cell. 96 (1): 99–110. doi:10.1016/S0092-8674(00)80963-0. PMID 9989501.
^ Andrade MA, Bork P (October 1995). "HEAT repeats in the Huntington's disease protein". Nat. Genet. 11 (2): 115–6. doi:10.1038/ng1095-115. PMID 7550332.

External links

Eukaryotic Linear Motif resource motif class LIG_PIKK_1
Eukaryotic Linear Motif resource motif class DOC_PIKK_1

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[cho_2006-1] Cho, Uhn Soo; Xu, Wenqing (1 November 2006). "Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme". Nature. 445 (7123): 53–57. doi:10.1038/nature05351.

[pmid9989501-2] Groves MR, Hanlon N, Turowski P, Hemmings BA, Barford D (January 1999). "The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs". Cell. 96 (1): 99–110. doi:10.1016/S0092-8674(00)80963-0. PMID 9989501.

[pmid7550332-3] Andrade MA, Bork P (October 1995). "HEAT repeats in the Huntington's disease protein". Nat. Genet. 11 (2): 115–6. doi:10.1038/ng1095-115. PMID 7550332.

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@@ Line 2: / Line 2: @@
 | Symbol = HEAT
 | Name = HEAT repeat
-| image = PDB 1b3u EBI.jpg
+| image = Alpha solenoid pp2a 2iae with single repeat center.png
 | width =
-| caption = Structure of the protein phosphatase 2A PR65/A subunit revealing the conformation of its 15 tandemly repeated HEAT motifs.<ref name="pmid9989501">{{cite journal |vauthors=Groves MR, Hanlon N, Turowski P, Hemmings BA, Barford D |title=The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs |journal=Cell |volume=96 |issue=1 |pages=99–110 |date=January 1999 |pmid=9989501 |doi= 10.1016/S0092-8674(00)80963-0|url=}}</ref>
+| caption = An example of an alpha solenoid structure composed of 15 [[HEAT repeat]]s. The [[protein phosphatase 2A]] regulatory subunit is shown with the [[N-terminus]] in blue at bottom and the [[C-terminus]] in red at top. A single [[helix-turn-helix]] motif is shown in the center with the outer helix in pink, the inner helix in green, and the turn in white. From {{PDB|2IAE}}.<ref name="cho_2006">{{cite journal|last1=Cho|first1=Uhn Soo|last2=Xu|first2=Wenqing|title=Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme|journal=Nature|date=1 November 2006|volume=445|issue=7123|pages=53–57|doi=10.1038/nature05351}}</ref><ref name="pmid9989501">{{cite journal |vauthors=Groves MR, Hanlon N, Turowski P, Hemmings BA, Barford D |title=The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs |journal=Cell |volume=96 |issue=1 |pages=99–110 |date=January 1999 |pmid=9989501 |doi= 10.1016/S0092-8674(00)80963-0|url=}}</ref>
 | Pfam = PF02985
 | InterPro = IPR000357
@@ Line 17: / Line 17: @@
 }}
-The '''HEAT repeat domain''' is a [[solenoid protein domain]] found in a number of [[cytoplasm]]ic proteins including the four that the give rise to the acronym '''HEAT''' ([[huntingtin|<u>'''H'''</u>untingtin]], elongation factor 3 (<u>'''E'''</u>F3), [[protein phosphatase 2]]A (PP2<u>'''A'''</u>), and the yeast kinase <u>'''T'''</u>OR1).<ref name="pmid7550332">{{cite journal |vauthors=Andrade MA, Bork P | title = HEAT repeats in the Huntington's disease protein | journal = Nat. Genet. | volume = 11 | issue = 2 | pages = 115–6 |date=October 1995 | pmid = 7550332 | doi = 10.1038/ng1095-115 | url =  }}</ref> HEAT repeats form rod-like helical structures which are involved in intracellular transport; they are structurally related to [[armadillo repeats]]. The nuclear transport protein [[KPNB1|importin beta]] contains 19 HEAT repeats.
+A '''HEAT repeat''' is [[tandem repeat]] protein [[structural motif]] composed of two [[alpha helices]] linked by a short loop. HEAT repeats can form [[alpha solenoid]]s, a type of [[solenoid protein domain]] found in a number of [[cytoplasm]]ic proteins. The name "HEAT" is an acronym for four proteins in which this repeat structure is found: [[huntingtin|<u>'''H'''</u>untingtin]], elongation factor 3 (<u>'''E'''</u>F3), [[protein phosphatase 2]]A (PP2<u>'''A'''</u>), and the yeast kinase <u>'''T'''</u>OR1.<ref name="pmid7550332">{{cite journal |vauthors=Andrade MA, Bork P | title = HEAT repeats in the Huntington's disease protein | journal = Nat. Genet. | volume = 11 | issue = 2 | pages = 115–6 |date=October 1995 | pmid = 7550332 | doi = 10.1038/ng1095-115 | url =  }}</ref> HEAT repeats form extended superhelical structures which are often involved in intracellular transport; they are structurally related to [[armadillo repeats]]. The nuclear transport protein [[KPNB1|importin beta]] contains 19 HEAT repeats.
 ==References==