Receptor modulator: Difference between revisions
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A '''receptor modulator''', or '''receptor ligand''', is a |
A '''receptor modulator''', or '''receptor ligand''', is a general term for a substance, endogenous or exogenous, that binds to and regulates the activity of chemical [[receptor (biochemistry)|receptor]]s. They are [[ligand (biochemistry)|ligand]]s that can act on different parts of receptors and regulate activity in a positive, negative, or neutral direction with varying degrees of efficacy. Categories of these modulators include [[receptor agonist]]s and [[receptor antagonist]]s, as well as receptor [[partial agonist]]s, [[inverse agonist]]s, orthosteric modulators, and [[allosteric modulator]]s<ref>{{Cite journal|last=Westen|first=Gerard J. P. van|last2=Gaulton|first2=Anna|last3=Overington|first3=John P.|date=2014-04-03|title=Chemical, Target, and Bioactive Properties of Allosteric Modulation|url=https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1003559|journal=PLOS Computational Biology|language=en|volume=10|issue=4|pages=e1003559|doi=10.1371/journal.pcbi.1003559|issn=1553-7358|pmc=PMC3974644|pmid=24699297}}</ref>. Examples of receptor modulators in modern medicine include CFTR modulators<ref>{{Cite web|last=Bethesda|first=Cystic Fibrosis Foundation 4550 Montgomery Ave Suite 1100 N.|last2=Md 20814301-951-4422 800-344-4823|title=CFTR Modulator Therapies|url=https://www.cff.org/Life-With-CF/Treatments-and-Therapies/Medications/CFTR-Modulator-Therapies/|access-date=2020-12-08|website=www.cff.org|language=en}}</ref>, selective androgen receptor modulators (SARMs), and muscarinic ACh receptor modulators. |
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==See also== |
==See also== |
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Revision as of 22:42, 8 December 2020
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A receptor modulator, or receptor ligand, is a general term for a substance, endogenous or exogenous, that binds to and regulates the activity of chemical receptors. They are ligands that can act on different parts of receptors and regulate activity in a positive, negative, or neutral direction with varying degrees of efficacy. Categories of these modulators include receptor agonists and receptor antagonists, as well as receptor partial agonists, inverse agonists, orthosteric modulators, and allosteric modulators[1]. Examples of receptor modulators in modern medicine include CFTR modulators[2], selective androgen receptor modulators (SARMs), and muscarinic ACh receptor modulators.
See also
References
- ^ Westen, Gerard J. P. van; Gaulton, Anna; Overington, John P. (2014-04-03). "Chemical, Target, and Bioactive Properties of Allosteric Modulation". PLOS Computational Biology. 10 (4): e1003559. doi:10.1371/journal.pcbi.1003559. ISSN 1553-7358. PMC 3974644. PMID 24699297.
{{cite journal}}: CS1 maint: PMC format (link) CS1 maint: unflagged free DOI (link) - ^ Bethesda, Cystic Fibrosis Foundation 4550 Montgomery Ave Suite 1100 N.; Md 20814301-951-4422 800-344-4823. "CFTR Modulator Therapies". www.cff.org. Retrieved 2020-12-08.
{{cite web}}: CS1 maint: numeric names: authors list (link)
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