The 2012 Jalisco Open was a professional tennis tournament played on hard courts. It was the second edition of the tournament which was part of the 2012 ATP Challenger Tour. It took place in Guadalajara, Mexico between 12 and 18 March 2012.
Singles main draw entrants
- 1 Rankings are as of March 5, 2012.
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw: