AA amyloidosis

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AA amyloidosis
Classification and external resources
ICD-10 E85
ICD-9 277.3
DiseasesDB 16
eMedicine med/3388

AA amyloidosis is a form of amyloidosis, i.e. a disease characterized by the abnormal deposition of fibers of insoluble protein in the extracellular space of various tissues and organs. In AA amyloidosis, the deposited protein is serum amyloid A protein (SAA), an acute-phase protein which is normally soluble and whose plasma concentration is highest during inflammation.[1]

Causes[edit]

AA amyloidosis is a complication of a number of inflammatory diseases and infections.:[2]

Pathology[edit]

The SAA protein is mainly deposited in the liver, spleen and kidney, and AA amyloidosis can lead to nephrotic syndrome.[6][7]

Current Clinical Research[edit]

Kiacta - (eprodisate disodium) is currently being evaluated as a protector of renal function in AA amyloidosis.

References[edit]

  1. ^ Lachmann HJ, Goodman HJ, Gilbertson JA, et al. (June 2007). "Natural history and outcome in systemic AA amyloidosis". New England Journal of Medicine 356 (23): 2361–71. doi:10.1056/NEJMoa070265. PMID 17554117. 
  2. ^ Chapter 5 in: Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson. Robbins Basic Pathology. Philadelphia: Saunders. ISBN 1-4160-2973-7.  8th edition.
  3. ^ d'Ythurbide, G; Kerrou, K; Brocheriou, I; Hertig, A (2012). "Reactive amyloidosis complicated by end-stage renal disease 28 years after liquid silicone injection in the buttocks". Case Reports 2012: bcr2012006803. doi:10.1136/bcr-2012-006803. PMID 23035166.  edit
  4. ^ Emekli, U; Tümerdem, B; Demiryont, M (2002). "Rupture of a silicone gel mammary prosthesis and amyloidosis: A case report". Aesthetic Plastic Surgery 26 (5): 383–7. doi:10.1007/s00266-002-2022-x. PMID 12432480.  edit
  5. ^ Goldman, A. B.; Bansal, M (1996). "Amyloidosis and silicone synovitis: Updated classification, updated pathophysiology, and synovial articular abnormalities". Radiologic clinics of North America 34 (2): 375–94, xi. PMID 8633122.  edit
  6. ^ "AA (Inflammatory) Amyloidosis". Medscape Reference. 
  7. ^ "AA Amyloidosis". BU Amyloid Treatment & Research Program. 

External links[edit]