|Classification and external resources|
AA amyloidosis is a form of amyloidosis, i.e. a disease characterized by the abnormal deposition of fibers of insoluble protein in the extracellular space of various tissues and organs. In AA amyloidosis, the deposited protein is serum amyloid A protein (SAA), an acute-phase protein which is normally soluble and whose plasma concentration is highest during inflammation.
AA amyloidosis is a complication of a number of inflammatory diseases and infections.:
- Dysimmune diseases
- Chronic infections
- Autoinflammatory diseases
- Chronic foreign body reaction
Current Clinical Research
Kiacta - (eprodisate disodium) is currently being evaluated as a protector of renal function in AA amyloidosis.
Transmission of amyloidosis
There is evidence that eating amyloid fibers may lead to amyloidosis. This evidence is based on studies in cattle, chickens, mice, and cheetahs. Thus, in a sense, SAA amyloidosis may be considered a contagious disease, although whether this occurs or is important in the development of naturally occurring amyloidosis remains unknown. Nevertheless, because amyloid fibers can be detected in muscle in low amounts, it raises some concern about whether people could develop amyloidosis as a result of ingesting meat from an animal with the disease.
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