(Baillet, 1866) Kamensky[disambiguation needed], 1905
Angiostrongylus vasorum, also known as French heartworm, is a species of parasitic nematode in the family Metastrongylidae. It causes the disease canine angiostrongylosis in dogs. It is not zoonotic, that is, it cannot be communicated to humans.
Not much is known about the biology of this species.
Females have a barbers pole appearance.
The life cycle begins when L3 larvae are ingested by a definitive host, primarily the fox or dog. This can be through eating mollusc (intermediate hosts), frogs (paraentenic hosts), or from food infected with slime from the slugs or snails. The L3 larvae migrate to the mesenteric lymph nodes and moult to L4, and L5. The L5 larvae migrate through the portal circulation and through the liver and the adults end up at the pulmonary artery or right side of the heart.
The adults then mate and produce eggs. The eggs move to the alveolar capillaries via the circulation and hatch to L1 larvae. The L1 larvae burrow though the alveolar and are then coughed up and swallowed. L1 larvae are therefore passed in the faeces of infected cannids.
The L1 larvae infect intermediate hosts (primarily slugs and snails) by penetrating the foot of the mollusc and develop to L3 within.
Adult worms can live for 2 years. The pre-patent period is 6–10 weeks.
Pathology and diagnosis
Pathology is from both the adult worms, eggs and larvae.
Cardio-respiratory signs are one clinical symptom. Chronic, coughing, exercise intolerance, dyspnoea and tachypnoea in young dogs is due to blood vessels being blocked by adults, eggs and larvae.
The parasite also causes coagulopathies. Haematomas and prolonged bleeding are as a result of thrombocytopaenia (where clotting factors are decreased due to them binding to antigen - antibody complexes). Clotting factors V and VIII are also reduced. Hypochromic anaemia is another symptom, also used in diagnosis and is due to the parasite interfering with haemoglobin synthesis.
Angiostrongylus vasorum also causes neurological damage. These present as ataxia, paresis, loss of vision, behavioural changes and seizures. All these symptoms are as a direct result of CNS haemorrhages.
Diagnosis is made from a combination of clinical signs and tests.
Imaging can show lung lesions in the peripheral lobes. Blood tests, showing eosinophillia, poor clotting ability and speed as well as hypochomric anemia all point towards a diagnosis. Some cases may also have hypercalcaemia the cause of this unknown but may relate to granulomatous inflammation and macrophage production of alpha 1 hydroxylase. Faecal examination using the Baerman technique are unreliable, as egg output is irregular and the pre-patent period of the parasite is relatively long. However this test is more sensitive than a faecal smear examination. Multiple samples help reduce the risk of a false negative but should not be relied upon.
Post mortem examination can also reveal the causative agent to be Angiosrongylus vasorum. Again, lung lesions (looking for mottles lungs) are seen. Subcutaneous haematomas and enlarged blood vessels are common. Another sign is endocarditis of the right side of the heart and the tricuspid valve.
- red fox Vulpes vulpes
- pampas fox Pseudalopex gymnocerus
- hoary fox Pseudalopex vetulus
- crab-eating fox Dusicyon thous
- wolf Canis lupus
- coyote Canis latrans
- African desert fox Fennecus zerda
- European badger Meles meles
Experimental intermediate hosts of Angiostrongylus vasorum include:
- slugs: Arion vulgaris (referred as Arion lusitanicus), Arion hortensis, Deroceras reticulatum, Limax flavus, Laevicaulis alte.
- land snails: Achatina fulica, Arianta arbustorum, Bradybaena similaris, Cepaea nemoralis, Cochlodina laminata, Eceparypha physana, Helix pomatia, Helix aspersa, Prosopeas javanicum, Subulina octona, Succinea putris.
- freshwater snails: Biomphalaria pfeifferi, Physa sp.
Experimental definitive hosts of Angiostrongylus vasorum include:
Up to 23% of foxes are infected in southeast England. 5% of patent infected dogs are clinically healthy. There is a correlation between high fox incidence and domestic dog incidence, logically leading to the assumption that the fox is an important wildlife reservoir of this parasite.
Other known areas include
- Ferdushy, T.; Kapel, C. M. O.; Webster, P.; Al-Sabi, M. N. S.; Grønvold, J. (2009). "The occurrence of Angiostrongylus vasorum in terrestrial slugs from forests and parks in the Copenhagen area, Denmark". Journal of Helminthology 83 (4): 379. doi:10.1017/S0022149X09377706. .</ref> Germany, Italy, Switzerland and Portugal
- Africa: Uganda
- Asia: Turkey and countries of the former USSR
- Northern America: Canada (Newfoundland), the United States
The area where this species is found is expanding.
It has also been reported from South America: Brazil and Colombia, but molecular analysis revealed that Angiostrongylus vasorum from Brazil has a different genotype. Thus it is possible that it is a different species in Brazil and in elsewhere in South America.
- Morgan, E. R.; Shaw, S. E.; Brennan, S. F.; De Waal, T. D.; Jones, B. R.; Mulcahy, G. (2005). "Angiostrongylus vasorum: A real heartbreaker". Trends in Parasitology 21 (2): 49–51. doi:10.1016/j.pt.2004.11.006. PMID 15664523.
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- Ash, L. R. (1970). "Diagnostic morphology of the third-stage larvae of Angiostrongylus cantonensis, Angiostrongylus vasorum, Aelurostrongylus abstrusus, and Anafilaroides rostratus (Nematoda: Metastrongyloidea)". The Journal of parasitology 56 (2): 249–253. PMID 5445821..
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