Arctigenin

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(−)-Arctigenin
(−)-Arctigenin.svg
Identifiers
CAS number 7770-78-7 N
PubChem 64981
ChemSpider 58506 YesY
MeSH arctigenin
ChEMBL CHEMBL435734 YesY
Jmol-3D images Image 1
Properties
Molecular formula C21H24O6
Molar mass 372.41166
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

Arctigenin is a lignan found in certain plants of the Asteraceae, including the greater burdock (Arctium lappa) and Saussurea heteromalla. It has shown antiviral[1] and anticancer[2] effects in glass. It is the aglycone of arctiin.

The use of arctigenin has been shown to be effective in a mouse model of Japanese encephalitis.[3]

References[edit]

  1. ^ Hayashi, K.; Narutaki, K.; Nagaoka, Y.; Hayashi, T.; Uesato, S. (2010). "Therapeutic effect of arctiin and arctigenin in immunocompetent and immunocompromised mice infected with influenza a virus". Biological & pharmaceutical bulletin 33 (7): 1199–1205. doi:10.1248/bpb.33.1199. PMID 20606313.  edit
  2. ^ Yang, S.; Ma, J.; Xiao, J.; Lv, X.; Li, X.; Yang, H.; Liu, Y.; Feng, S.; Zhang, Y. (2012). "Arctigenin Anti-Tumor Activity in Bladder Cancer T24 Cell Line Through Induction of Cell-Cycle Arrest and Apoptosis". The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology 295 (8): 1260–1266. doi:10.1002/ar.22497. PMID 22619087.  edit
  3. ^ Swarup V, Ghosh J, Mishra MK, Basu A (March 2008). "Novel strategy for treatment of Japanese encephalitis using arctigenin, a plant lignan". J. Antimicrob. Chemother. 61 (3): 679–88. doi:10.1093/jac/dkm503. PMID 18230688. 

External links[edit]

  • Arctigenin entry in the public domain NCI Dictionary of Cancer Terms

 This article incorporates public domain material from the U.S. National Cancer Institute document "Dictionary of Cancer Terms".