CSNK1E

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Casein kinase 1, epsilon
Protein CSNK1E PDB 1cki.png
PDB rendering based on 1cki.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CSNK1E ; CKIepsilon; HCKIE
External IDs OMIM600863 MGI1351660 HomoloGene121695 ChEMBL: 4937 GeneCards: CSNK1E Gene
EC number 2.7.11.1
RNA expression pattern
PBB GE CSNK1E 202332 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1454 27373
Ensembl ENSG00000213923 ENSMUSG00000022433
UniProt P49674 Q9JMK2
RefSeq (mRNA) NM_001894 NM_013767
RefSeq (protein) NP_001885 NP_038795
Location (UCSC) Chr 22:
38.69 – 38.79 Mb
Chr 15:
79.42 – 79.44 Mb
PubMed search [1] [2]

Casein kinase I isoform epsilon is an enzyme that in humans is encoded by the CSNK1E gene.[1][2]

The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate proteins of the Period family of circadian rhythm proteins. A homolog of this mammalian protein can be found in Drosophila melanogaster. Known as doubletime, this protein also plays a role in the phosphorylation of proteins involved in circadian rhythms. Two transcript variants encoding the same protein have been found for this gene.[3]

Interactions[edit]

CSNK1E has been shown to interact with PER1[4] and AXIN1.[5]

Inhibitors[edit]

Selective
Non-selective
  • PF-670462 (also inhibits CK1-δ)

References[edit]

  1. ^ Fish KJ, Cegielska A, Getman ME, Landes GM, Virshup DM (July 1995). "Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family". J Biol Chem 270 (25): 14875–83. doi:10.1074/jbc.270.25.14875. PMID 7797465. 
  2. ^ Sakanaka C, Leong P, Xu L, Harrison SD, Williams LT (December 1999). "Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function". Proc Natl Acad Sci USA 96 (22): 12548–52. doi:10.1073/pnas.96.22.12548. PMC 22983. PMID 10535959. 
  3. ^ "Entrez Gene: CSNK1E casein kinase 1, epsilon". 
  4. ^ Vielhaber, E; Eide E; Rivers A; Gao Z H; Virshup D M (July 2000). "Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon". Mol. Cell. Biol. (UNITED STATES) 20 (13): 4888–99. doi:10.1128/MCB.20.13.4888-4899.2000. ISSN 0270-7306. PMC 85940. PMID 10848614. 
  5. ^ Zhang, Yi; Qiu Wen-Jie; Chan Siu Chiu; Han Jiahuai; He Xi; Lin Sheng-Cai (May 2002). "Casein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathways". J. Biol. Chem. (United States) 277 (20): 17706–12. doi:10.1074/jbc.M111982200. ISSN 0021-9258. PMID 11884395.