Caloric reflex test
|Caloric reflex test|
In medicine, the caloric reflex test (sometimes termed 'vestibular caloric stimulation') is a test of the vestibulo-ocular reflex that involves irrigating cold or warm water or air into the external auditory canal.
It is commonly used by physicians, audiologists and other trained professionals to validate a diagnosis of asymmetric function in the peripheral vestibular system. Calorics are usually a subtest of the electronystagmography (ENG) battery of tests. It is one of several tests which can be used to test for brain stem death.
One novel use of this test has been to provide temporary pain relief from phantom limb pains in amputees  and paraplegics. It can also induce a temporary remission of anosognosia, the visual and personal aspects of hemispatial neglect, hemianesthesia, and other consequences of right hemispheric damage.
Technique and results 
Cold or warm water or air is irrigated into the external auditory canal, usually using a syringe. The temperature difference between the body and the injected water creates a convective current in the endolymph of the nearby horizontal semicircular canal. Hot and cold water produce currents in opposite directions and therefore a horizontal nystagmus in opposite directions. In patients with an intact brainstem:
- If the water is warm (44°C or above) endolymph in the ipsilateral horizontal canal rises, causing an increased rate of firing in the vestibular afferent nerve. This situation mimics a head turn to the ipsilateral side. Both eyes will turn toward the contralateral ear, with horizontal nystagmus to the ipsilateral ear.
- If the water is cold, relative to body temperature (30°C or below), the endolymph falls within the semicircular canal, decreasing the rate of vestibular afferent firing. The eyes then turn toward the ipsilateral ear, with horizontal nystagmus (quick horizontal eye movements) to the contralateral ear.
- Absent reactive eye movement suggests vestibular weakness of the horizontal semicircular canal of the side being stimulated.
In comatose patients with cerebral damage, the fast phase of nystagmus will be absent as this is controlled by the cerebrum. As a result, using cold water irrigation will result in deviation of the eyes toward the ear being irrigated. If both phases are absent, this suggests the patient's brainstem reflexes are also damaged and carries a very poor prognosis.
One mnemonic used to remember the FAST direction of nystagmus is COWS.
COWS: Cold Opposite, Warm Same.
Cold water = FAST phase of nystagmus to the side Opposite from the cold water filled ear
Warm water = FAST phase of nystagmus to the Same side as the warm water filled ear
In other words: Contralateral when cold is applied and ipsilateral when warm is applied
See also 
- André JM, Martinet N, Paysant J, Beis JM, Le Chapelain L (2001). "Temporary phantom limbs evoked by vestibular caloric stimulation in amputees". Neuropsychiatry Neuropsychol Behav Neurol 14 (3): 190–6. PMID 11513103.
- Le Chapelain L, Beis JM, Paysant J, André JM (February 2001). "Vestibular caloric stimulation evokes phantom limb illusions in patients with paraplegia". Spinal Cord 39 (2): 85–7. doi:10.1038/sj.sc.3101093. PMID 11402363.
- Robertson, Ian H.; Marshall, John C. (1993). Unilateral neglect: clinical and experimental studies. pp. 111–113. ISBN 978-0-86377-208-5. Retrieved 2010-06-04.
- Purves, D; et al (2004). Neuroscience. Sinauer.
- Nystagmus, Acquired at eMedicine
- Narenthiran G. Neurosurgery Quiz. Annals of Neurosurgery. Accessed on: August 17, 2006.
- Mueller-Jensen A, Neunzig HP, Emskötter T (April 1987). "Outcome prediction in comatose patients: significance of reflex eye movement analysis". J. Neurol. Neurosurg. Psychiatr. 50 (4): 389–92. doi:10.1136/jnnp.50.4.389. PMC 1031870. PMID 3585347.
- Webb C (1985). "COWS caloric test". Ann Emerg Med 14 (9): 938. doi:10.1016/S0196-0644(85)80671-5. PMID 4026002.