The game features hack and slash combat. Some of the fights end with quick time sequences. The player can use points to upgrade their weapons. In some sections of the game the player has their weapons removed and has to fight by hand. The gameplay features frequent loading times. The player can perform both light and heavy attacks and can hold buttons to release special attacks. The player can wield swords, bones, bows, and scorpion tails. The enemies have health bars with colors to show how much health they have left.
Like the film, the game received negative reviews from critics.GameSpot awarded the game 4.5 out of ten and said "Clash of the Titans is a predictable, derivative experience." PlayStation Universe awarded it 4.0 out of ten and said " It's one heck of a boring slog; a repetitive, mind-numbing game devoid of personality and lacking in style or substance."Eurogamer awarded it three out of ten and said "there simply isn't room in the limited confines of the hackandslash genre for a wonky also-ran like this."Game Informer awarded it 4 out of ten and said "Everything here has been done better in a dozen other games". The magazine Gamesmaster awarded it 45% and said "Yeah, it's bad". PSM3 Magazine UK awarded it 42% and called it "Consistently miserable." The game has a 41/100 rating on Metacritic.The Guardian awarded it two out of five and called it a "frustrating player experience".