DAZ associated protein 1

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DAZ associated protein 1
Protein DAZAP1 PDB 2dgs.png
PDB rendering based on 2dgs.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols DAZAP1 ; MGC19907
External IDs OMIM607430 MGI1917498 HomoloGene137331 GeneCards: DAZAP1 Gene
RNA expression pattern
PBB GE DAZAP1 218443 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 26528 70248
Ensembl ENSG00000071626 ENSMUSG00000069565
UniProt Q96EP5 Q9JII5
RefSeq (mRNA) NM_018959 NM_001122604
RefSeq (protein) NP_061832 NP_001116076
Location (UCSC) Chr 19:
1.41 – 1.44 Mb
Chr 10:
80.26 – 80.29 Mb
PubMed search [1] [2]

DAZ-associated protein 1 is a protein that in humans is encoded by the DAZAP1 gene.[1][2]

Function[edit]

In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ (Deleted in Azoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL also involved in germ cell development and gametogenesis. This gene encodes an RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL. Two isoforms are encoded by transcript variants of this gene.[2]

Interactions[edit]

DAZ associated protein 1 has been shown to interact with DAZ1.[3]

References[edit]

  1. ^ Tsui S, Dai T, Roettger S, Schempp W, Salido EC, Yen PH (August 2000). "Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1". Genomics 65 (3): 266–73. doi:10.1006/geno.2000.6169. PMID 10857750. 
  2. ^ a b "Entrez Gene: DAZAP1 DAZ associated protein 1". 
  3. ^ Tsui, S; Dai T; Roettger S; Schempp W; Salido E C; Yen P H (May 2000). "Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1". Genomics (UNITED STATES) 65 (3): 266–73. doi:10.1006/geno.2000.6169. ISSN 0888-7543. PMID 10857750. 

Further reading[edit]