DDX10

From Wikipedia, the free encyclopedia
Jump to: navigation, search
DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
Protein DDX10 PDB 2pl3.png
PDB rendering based on 2pl3.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols DDX10 ; HRH-J8
External IDs OMIM601235 MGI1924841 HomoloGene20922 GeneCards: DDX10 Gene
EC number 3.6.4.13
RNA expression pattern
PBB GE DDX10 204977 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1662 77591
Ensembl ENSG00000178105 ENSMUSG00000053289
UniProt Q13206 Q80Y44
RefSeq (mRNA) NM_004398 NM_029936
RefSeq (protein) NP_004389 NP_084212
Location (UCSC) Chr 11:
108.54 – 108.81 Mb
Chr 9:
53.1 – 53.25 Mb
PubMed search [1] [2]

Probable ATP-dependent RNA helicase DDX10 is an enzyme that in humans is encoded by the DDX10 gene.[1][2]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it may be involved in ribosome assembly. Fusion of this gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies.[2]

References[edit]

  1. ^ Savitsky K, Ziv Y, Bar-Shira A, Gilad S, Tagle DA, Smith S, Uziel T, Sfez S, Nahmias J, Sartiel A, Eddy RL, Shows TB, Collins FS, Shiloh Y, Rotman G (Jan 1997). "A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23". Genomics 33 (2): 199–206. doi:10.1006/geno.1996.0184. PMID 8660968. 
  2. ^ a b "Entrez Gene: DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10". 

Further reading[edit]