RIG-I (retinoic acid-inducible gene 1) is a RIG-I-like receptordsRNAhelicaseenzyme that is encoded (in humans) by the DDX58gene. RIG-I is part of the RIG-I-like receptor (RLR) family, which also includes MDA5 and LGP2, and functions as a pattern recognition receptor that is a sensor for viruses. RIG-I typically recognizes short (< 4000nt) 5′triphosphate dsRNA. RIG-I and MDA5 are involved in activating MAVS and triggering an antiviral response. For many viruses, effective RIG-I-mediated antiviral responses are dependent on functionally active LGP2.
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. RIG-I contains a RNA helicase-DEAD box motifs and a caspase recruitment domain (CARD). RIG-I is involved in viral double-stranded (ds) RNA recognition and the regulation of immune response.
Cui XF, Imaizumi T, Yoshida H, et al. (2005). "Retinoic acid-inducible gene-I is induced by interferon-gamma and regulates the expression of interferon-gamma stimulated gene 15 in MCF-7 cells.". Biochem. Cell Biol.82 (3): 401–5. doi:10.1139/o04-041. PMID15181474.
Yoneyama M, Kikuchi M, Natsukawa T, et al. (2004). "The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.". Nat. Immunol.5 (7): 730–7. doi:10.1038/ni1087. PMID15208624.
Imaizumi T, Yagihashi N, Hatakeyama M, et al. (2004). "Expression of retinoic acid-inducible gene-I in vascular smooth muscle cells stimulated with interferon-gamma.". Life Sci.75 (10): 1171–80. doi:10.1016/j.lfs.2004.01.030. PMID15219805.
Imaizumi T, Yagihashi N, Hatakeyama M, et al. (2005). "Upregulation of retinoic acid-inducible gene-I in T24 urinary bladder carcinoma cells stimulated with interferon-gamma.". Tohoku J. Exp. Med.203 (4): 313–8. doi:10.1620/tjem.203.313. PMID15297736.
Imaizumi T, Hatakeyama M, Yamashita K, et al. (2004). "Interferon-gamma induces retinoic acid-inducible gene-I in endothelial cells.". Endothelium11 (3-4): 169–73. doi:10.1080/10623320490512156. PMID15370293.
Sakaki H, Imaizumi T, Matsumiya T, et al. (2005). "Retinoic acid-inducible gene-I is induced by interleukin-1beta in cultured human gingival fibroblasts.". Oral Microbiol. Immunol.20 (1): 47–50. doi:10.1111/j.1399-302X.2005.00181.x. PMID15612946.
Li K, Chen Z, Kato N, et al. (2005). "Distinct poly(I-C) and virus-activated signaling pathways leading to interferon-beta production in hepatocytes.". J. Biol. Chem.280 (17): 16739–47. doi:10.1074/jbc.M414139200. PMID15737993.
Yoneyama M, Kikuchi M, Matsumoto K, et al. (2005). "Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity.". J. Immunol.175 (5): 2851–8. PMID16116171.
Seth RB, Sun L, Ea CK, Chen ZJ (2005). "Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3.". Cell122 (5): 669–82. doi:10.1016/j.cell.2005.08.012. PMID16125763.
Kawai T, Takahashi K, Sato S, et al. (2005). "IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction.". Nat. Immunol.6 (10): 981–8. doi:10.1038/ni1243. PMID16127453.
Meylan E, Curran J, Hofmann K, et al. (2005). "Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus.". Nature437 (7062): 1167–72. doi:10.1038/nature04193. PMID16177806.