After McGhehey retired from snowboarding due to injury, he got a job at a skate shop in Portland. There he filmed some of his ideas and stunts on a small scale; he was soon spotted by Jackass director Jeff Tremaine, who put him on the Jackass team. McGhehey later appeared in all three Jackass films. Ehren's motto when performing stunts on Jackass is "Safety First". McGhehey is often referred to by his nickname "Danger Ehren" by fellow Jackass cast and crew, not least due to his tendency to injure himself/lose teeth in the pursuit of stunts. He is the butt of many jokes by the Jackass crew, most notably and one of Johnny Knoxville's favorite, the infamous "Terror Taxi" in Jackass Number Two. In a stunt where Ehren played a terrorist passenger in a taxicab where he unknowingly wore a "pube beard" made up from his co-stars.
Ehren McGhehey operated a skateboarding apparel shop called Danger Valley, which he founded in his hometown of McMinnville, Oregon in 2007. McGhehey closed the business in 2013 due to management issues.