|Born||October 16, 1958|
|Alma mater||SUNY-Binghamton, Brandeis University, University of Colorado at Boulder|
|Doctoral advisor||William Jencks|
|Other academic advisors||Tom Cech|
|Notable awards||William C. Rose Award (2010)|
Daniel Herschlag (born October 16, 1958) is an American biochemist and Professor of Biochemistry at the Stanford University School of Medicine. His research uses an interdisciplinary approach to advance our understanding of the fundamental behavior of RNA and proteins. He is well known for his application of rigorous kinetic and mechanistic approaches to RNA and protein systems.
Herschlag received a B.S. in Biochemistry from SUNY-Binghamton in 1982. He began his graduate studies at University of Minnesota then moved on to complete his PhD in Biochemistry at Brandeis University under W.P. Jencks in 1988.
Herschlag was a Helen Hay Whitney Postdoctoral Fellow at the University of Colorado at Boulder from 1989 to 1992. He conducted post-doctoral research on the mechanism of the newly discovered RNA self-splicing reaction in the lab of Tom Cech.
In 1992, Herschlag joined the faculty of the Biochemistry department in the Stanford University School of Medicine, earning tenure in 1997. He was promoted to full professor in 2002.
- Pfizer Award in Enzyme Chemistry, 1997
- Cope Scholar Award from the American Chemical Society 2000
- ASBMB William Rose Award 2010
- Herschlag, Daniel; Cech, Thomas R. (1990). "DNA cleavage catalysed by the ribozyme from Tetrahymena". Nature 344 (6265): 405–9. Bibcode:1990Natur.344..405H. doi:10.1038/344405a0. PMID 1690858.
- Herschlag, Daniel (1995). "RNA Chaperones and the RNA Folding Problem". The Journal of Biological Chemistry 270 (36): 20871–4. doi:10.1074/jbc.270.36.20871. PMID 7545662.
- O'Brien, Patrick J; Herschlag, Daniel (1999). "Catalytic promiscuity and the evolution of new enzymatic activities". Chemistry & Biology 6 (4): R91–R105. doi:10.1016/S1074-5521(99)80033-7. PMID 10099128.
- Russell, Rick; Zhuang, Xiaowei; Babcock, Hazen P.; Millett, Ian S.; Doniach, Sebastian; Chu, Steven; Herschlag, Daniel (2001). "Exploring the Folding Landscape of a Structured RNA". Proceedings of the National Academy of Sciences 99 (1): 155–60. Bibcode:2002PNAS...99..155R. doi:10.1073/pnas.221593598. JSTOR 3057508. PMC 117531. PMID 11756689.
- Zalatan, Jesse G.; Herschlag, Daniel (2006). "Alkaline Phosphatase Mono- and Diesterase Reactions: Comparative Transition State Analysis". Journal of the American Chemical Society 128 (4): 1293–303. doi:10.1021/ja056528r. PMC 2538955. PMID 16433548.
- Solomatin, Sergey V.; Greenfeld, Max; Chu, Steven; Herschlag, Daniel (2010). "Multiple native states reveal persistent ruggedness of an RNA folding landscape". Nature 463 (7281): 681–4. Bibcode:2010Natur.463..681S. doi:10.1038/nature08717. PMC 2818749. PMID 20130651.
Herschlag currently lives in Menlo Park, CA with his wife and two children.
- "Daniel Herschlag named this year’s William C. Rose Award winner". ASBMB. Retrieved 7 April 2013.
- "Meet Dr. Herschlag from Stanford University". UCSF. 6 September 2012. Retrieved 7 April 2013.
- "Helen Hay Whitney Foundation award list".
- "Stanford Dean's Newsletter".
- "Stanford University School of Medicine Leadership List".
- "Pfizer Awardees List" (PDF).
- "Cope Scholar Award Announcement".
- "ASBMB William Rose award announcement".
- Herschlag Lab Website
- Stanford University School of Medicine Biochemistry Department
- Stanford Community Academic Profile, Daniel Herschlag
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