Gregory Petsko

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Gregory Petsko
Gregory Petsko.png
Gregory Petsko
Institutions Brandeis University
Wayne State University
Max Planck Institute
University of Oxford
Princeton University
Alma mater Princeton University
Thesis Structural studies of triose phosphate isomerase. (1974)
Doctoral advisor David Chilton Phillips
Notable awards Rhodes Scholarship
Member of the U.S. National Academy of Sciences

Gregory A. Petsko is an American biochemist and member of the National Academy of Sciences. He is the Gyula and Katica Tauber Professor of Biochemistry & Chemistry at Brandeis University.


Petsko was an undergraduate at Princeton University. He received a Rhodes Scholarship, and obtained his doctorate from the University of Oxford supervised David Chilton Phillips studying Triosephosphate isomerase.


Petsko's independent academic career included stints at Wayne State University, the Massachusetts Institute of Technology, the Max Planck Institute, and, since 1991, Brandeis University, where he is Professor of Biochemistry and of Chemistry and Director of the Rosenstiel Center. He is Past-President of the American Society for Biochemistry and Molecular Biology. In April 2010, he was elected to the American Philosophical Society.[1]


Petsko's research interests[2] are in protein crystallography. He is co-author with Dagmar Ringe of Protein Structure and Function.[3] He is also the author of a monthly column in Genome Biology[4][5] modelled after an amusing column in Current Biology penned by Sydney Brenner.[6] Petsko is best known for using X-ray crystallography to solve important problems in protein function including protein dynamics as a function of temperature and problems in mechanistic enzymology.[7][8][9]

At MIT and Brandeis, he trained a large number of current leaders in structural molecular biology who now have leadership roles in science. These individuals include:


  1. ^
  2. ^ List of publications from Microsoft Academic Search
  3. ^ Petsko, Gregory A. (2008). Protein Structure and Function (Primers in Biology). Oxford [Oxfordshire]: Oxford University Press. ISBN 0-19-955684-9. 
  4. ^ Petsko, G. A. (2000). "The grail problem". Genome Biology 1 (1): comment002.comment001–comment002.comment001. doi:10.1186/gb-2000-1-1-comment002. PMC 138819. PMID 11104515.  edit
  5. ^ Petsko, G. A. (2012). "A case of the flu". Genome Biology 13 (2): 146. doi:10.1186/gb-2012-13-2-146. PMC 3334562. PMID 22364112.  edit
  6. ^ Brenner, S. (2002). "The worm's turn". Current biology : CB 12 (21): R713. PMID 12419193.  edit
  7. ^ Frauenfelder, H.; Petsko, G. A.; Tsernoglou, D. (1979). "Temperature-dependent X-ray diffraction as a probe of protein structural dynamics". Nature 280 (5723): 558–563. doi:10.1038/280558a0. PMID 460437.  edit
  8. ^ Schlichting, I.; Berendzen, J.; Chu, K.; Stock, A. M.; Maves, S. A.; Benson, D. E.; Sweet, R. M.; Ringe, D.; Petsko, G. A.; Sligar, S. G. (2000). "The Catalytic Pathway of Cytochrome P450cam at Atomic Resolution". Science 287 (5458): 1615–1622. doi:10.1126/science.287.5458.1615. PMID 10698731.  edit
  9. ^ Karplus, M.; Petsko, G. A. (1990). "Molecular dynamics simulations in biology". Nature 347 (6294): 631–639. doi:10.1038/347631a0. PMID 2215695.  edit