Burke has 3 solo albums, a Celtic compilation and a maxi single, and can be heard on many anime and video game soundtracks, including Turn-A Gundam, Haibane Renmei, Vandread, Tokimeki Memorial, Tales of Legendia, Final Fantasy, and Metal Gear Solid: Peace Walker. She has acted in several video games, such as OutRun 2, the Shenmue, and the Silent Hill series, and has been credited in several OVA's such as Strange Dawn, Hoshi no Koe and Trip Trek and the anime series Magical Girl Lyrical Nanoha and Magical Girl Lyrical Nanoha A's. Donna is the voice of Hel in Boktai, Ursula in Lunar Knights, and Norah in the Sega game "Let's go Jungle". Additionally, she has been credited as a lyricist for numerous Japanese TV commercials, anime songs, and J-pop groups.
Burke's voice is well known in Japan as the guidance voice since 2003 on the Tokaido Shinkansen bullet train system. Her voice is heard in Narita Airport Northwest Airlines lounges and as the English guidance for the Emperor Showa Memorial Museum. Burke has worked as a freelance announcer at NHK since 1999 on various documentaries, NHK Specials and reading the nightly bilingual news. She narrated the award winning Climate in Crisis - Part 1 which won the 2007 silver medal (Environment Ecology) at the New York Television Festival and the EARTH VISION AWARD in 2007 at the Tokyo Global Environmental Film Festival.
Burke started an agency called Dagmusic in 2004 for other foreign singers, voice actors, composers and musicians living in Tokyo. She splits her time between music and Hotteeze, a company she created to export Japanese heat pads worldwide.
- Additional Voices in Shenmue and Shenmue II
- Angela Orosco in Silent Hill 2 and Silent Hill HD Collection
- Jenny the Bat in Bloody Roar: Primal Fury/Bloody Roar: Extreme
- Operator of the Lysithea in Voices of a Distant Star both Japanese and English for the DVD.
- Claudia Wolf in Silent Hill 3 (Pre-HD Collection)
- Storytelling Narrator in Final Fantasy Crystal Chronicles
- Hel in Boktai: The Sun Is in Your Hand
- Uranus in Bloody Roar 4
- Raising Heart in all Magical Girl Lyrical Nanoha series
- Anesthesia / Dr. Cutter in Rumble Roses
- Ursula in Lunar Knights
- Vanessa Lewis in Virtua Quest and Virtua Fighter 5
- Mature in The King of Fighters XII (English voice)
- Charo's mother in Little Charo 2 NHK Kanon
- Christina in Diabolical Pitch
- Voice of the IDroid in Metal Gear Solid: Ground Zeroes (English voice)
- Lost and Found (2001)
- Éirí na Gréine (2001)
- Donna Burke with the David Silverman Quartet (2002)
- Goodbye Nakamura [Single] (2004)
- "Blue Nights" (2005)
- The "Yamaha Educational Children's Songs" CDs / Various Artists (1997-2003 - vocals for several tracks)
- "Para Para Panic" CDs - Volumes 2, 3, 4, 5, 6 & 7 / Various Artists (2000 - vocals for several tracks)
- Konami Beatmania - "Hero" / Various Artists (2000 - vocals for several tracks)
- "ABBA Ibiza Caliente Mix" / ABBA, Sabu (2001 - vocals for several tracks)
- Vandread: Original OVA Soundtrack 1 / Yasunori Iwasaki, Various Artists (2001 - vocal for "What a Wonderful World)
- Vandread: Original OVA Soundtrack 2 / Yasunori Iwasaki, Various Artists (2001 - vocal and lyrics for "Somedays")
- Turn-A Gundam: Original Movie Soundtrack - "Wakusei no Gogo, Bokura wa Kisu wo Shita" / Yoko Kanno (2002 - vocal for "After All")
- "Seven"/ V6 (2002 - lyrics for "One")
- Final Fantasy Crystal Chronicles - "Morning Sky" and "Moonless Starry Night"
- "RWC Music Database: Royalty-Free Music" / Various Artists (2003 - vocals for several tracks)
- Haibane Renmei: Original OVA Soundtrack 1 - "Hanenone (ハネノネ)" / Kow Otani, Masumi Sakaue (2003 - vocal and lyrics for "Wondering")
- Konami's Dance Dance Revolution SuperNOVA - "Star Gate Heaven" and "Star Gate Heaven (FUTURE LOVE Mix)" / Various Artists (2006 - in collaboration with Sōta Fujimori)
- Tokimeki Memorial 2 Substories: Dancing Summer Vacation - "Hero ~Dancing Summer Mix English Ver.~"
- Sega Outrun 2 - "Life Was A Bore"
- The Last Remnant - "Journey's End"
- Metal Gear Solid: Peace Walker - "Heavens Divide"
- God Eater - "God and Man"
- Tales of Legendia - "Hotarubi" and "My Tales" with Gab Desmond
- Metal Gear Solid V: The Phantom Pain - "Sins of The Father"