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FAT tumor suppressor homolog 4 (Drosophila)
Symbols FAT4 ; CDHF14; CDHR11; FAT-J; FATJ; NBLA00548
External IDs OMIM612411 MGI3045256 HomoloGene14377 GeneCards: FAT4 Gene
Species Human Mouse
Entrez 79633 329628
Ensembl ENSG00000196159 ENSMUSG00000046743
UniProt Q6V0I7 Q2PZL6
RefSeq (mRNA) NM_024582 NM_183221
RefSeq (protein) NP_078858 NP_899044
Location (UCSC) Chr 4:
126.24 – 126.41 Mb
Chr 3:
38.89 – 39.01 Mb
PubMed search [1] [2]

Protocadherin Fat 4, also known as cadherin family member 14 (CDHF14) or FAT tumor suppressor homolog 4 (FAT4), is a protein that in humans is encoded by the FAT4 gene.[1][2]

FAT4 is associated with the Hippo signaling pathway.[3]

Clinical significance[edit]

Mutations in FAT4 are associated to Hennekam syndrome .[4]


  1. ^ "Entrez Gene: FAT tumor suppressor homolog 4 (Drosophila)". 
  2. ^ Höng JC, Ivanov NV, Hodor P, Xia M, Wei N, Blevins R, Gerhold D, Borodovsky M, Liu Y (March 2004). "Identification of new human cadherin genes using a combination of protein motif search and gene finding methods". J. Mol. Biol. 337 (2): 307–17. doi:10.1016/j.jmb.2004.01.026. PMID 15003449. 
  3. ^ Qi C, Zhu YT, Hu L, Zhu YJ (February 2009). "Identification of Fat4 as a candidate tumor suppressor gene in breast cancers". Int. J. Cancer 124 (4): 793–8. doi:10.1002/ijc.23775. PMC 2667156. PMID 19048595. 
  4. ^ Alders, M; Al-Gazali, L; Cordeiro, I; Dallapiccola, B; Garavelli, L; Tuysuz, B; Salehi, F; Haagmans, M. A.; Mook, O. R.; Majoie, C. B.; Mannens, M. M.; Hennekam, R. C. (2014). "Hennekam syndrome can be caused by FAT4 mutations and be allelic to Van Maldergem syndrome". Human Genetics 133: 1161–1167. doi:10.1007/s00439-014-1456-y. PMID 24913602.  edit

Further reading[edit]