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Growth factor receptor-bound protein 14
Protein GRB14 PDB 2aug.png
PDB rendering based on 2aug.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbol GRB14
External IDs OMIM601524 MGI1355324 HomoloGene3303 GeneCards: GRB14 Gene
RNA expression pattern
PBB GE GRB14 206204 at tn.png
More reference expression data
Species Human Mouse
Entrez 2888 50915
Ensembl ENSG00000115290 ENSMUSG00000026888
UniProt Q14449 Q9JLM9
RefSeq (mRNA) NM_004490 NM_016719
RefSeq (protein) NP_004481 NP_057928
Location (UCSC) Chr 2:
165.35 – 165.48 Mb
Chr 2:
64.91 – 65.02 Mb
PubMed search [1] [2]

Growth factor receptor-bound protein 14 is a protein that in humans is encoded by the GRB14 gene.[1][2]

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Transcript variants have been reported for this gene, but their full-length natures have not been determined to date.[2]


GRB14 has been shown to interact with Epidermal growth factor receptor,[3] Fibroblast growth factor receptor 1[4] and TNKS2.[5]


  1. ^ Baker E, Sutherland GR, Sutherland RL, Daly RJ (February 1997). "Assignment of the human GRB14 gene to chromosome 2q22-q24 by fluorescence in situ hybridization". Genomics 36 (1): 218–220. doi:10.1006/geno.1996.0453. PMID 8812444. 
  2. ^ a b "Entrez Gene: GRB14 growth factor receptor-bound protein 14". 
  3. ^ Daly, R J; Sanderson G M; Janes P W; Sutherland R L (May 1996). "Cloning and characterization of GRB14, a novel member of the GRB7 gene family". J. Biol. Chem. (UNITED STATES) 271 (21): 12502–12510. doi:10.1074/jbc.271.21.12502. ISSN 0021-9258. PMID 8647858. 
  4. ^ Reilly, J F; Mickey G; Maher P A (March 2000). "Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partner". J. Biol. Chem. (UNITED STATES) 275 (11): 7771–7778. doi:10.1074/jbc.275.11.7771. ISSN 0021-9258. PMID 10713090. 
  5. ^ Lyons, R J; Deane R; Lynch D K; Ye Z S; Sanderson G M; Eyre H J; Sutherland G R; Daly R J (May 2001). "Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14". J. Biol. Chem. (United States) 276 (20): 17172–17180. doi:10.1074/jbc.M009756200. ISSN 0021-9258. PMID 11278563. 

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