GRB14

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Growth factor receptor-bound protein 14
Protein GRB14 PDB 2aug.png
PDB rendering based on 2aug.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbol GRB14
External IDs OMIM601524 MGI1355324 HomoloGene3303 GeneCards: GRB14 Gene
RNA expression pattern
PBB GE GRB14 206204 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2888 50915
Ensembl ENSG00000115290 ENSMUSG00000026888
UniProt Q14449 Q9JLM9
RefSeq (mRNA) NM_004490 NM_016719
RefSeq (protein) NP_004481 NP_057928
Location (UCSC) Chr 2:
165.35 – 165.48 Mb
Chr 2:
64.91 – 65.02 Mb
PubMed search [1] [2]

Growth factor receptor-bound protein 14 is a protein that in humans is encoded by the GRB14 gene.[1][2]

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Transcript variants have been reported for this gene, but their full-length natures have not been determined to date.[2]

Interactions[edit]

GRB14 has been shown to interact with Epidermal growth factor receptor,[3] Fibroblast growth factor receptor 1[4] and TNKS2.[5]

References[edit]

  1. ^ Baker E, Sutherland GR, Sutherland RL, Daly RJ (February 1997). "Assignment of the human GRB14 gene to chromosome 2q22-q24 by fluorescence in situ hybridization". Genomics 36 (1): 218–220. doi:10.1006/geno.1996.0453. PMID 8812444. 
  2. ^ a b "Entrez Gene: GRB14 growth factor receptor-bound protein 14". 
  3. ^ Daly, R J; Sanderson G M; Janes P W; Sutherland R L (May 1996). "Cloning and characterization of GRB14, a novel member of the GRB7 gene family". J. Biol. Chem. (UNITED STATES) 271 (21): 12502–12510. doi:10.1074/jbc.271.21.12502. ISSN 0021-9258. PMID 8647858. 
  4. ^ Reilly, J F; Mickey G; Maher P A (March 2000). "Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partner". J. Biol. Chem. (UNITED STATES) 275 (11): 7771–7778. doi:10.1074/jbc.275.11.7771. ISSN 0021-9258. PMID 10713090. 
  5. ^ Lyons, R J; Deane R; Lynch D K; Ye Z S; Sanderson G M; Eyre H J; Sutherland G R; Daly R J (May 2001). "Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14". J. Biol. Chem. (United States) 276 (20): 17172–17180. doi:10.1074/jbc.M009756200. ISSN 0021-9258. PMID 11278563. 

Further reading[edit]