HBQ1

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Hemoglobin, theta 1
Identifiers
Symbol HBQ1
External IDs OMIM142240 MGI3613460 HomoloGene3895 GeneCards: HBQ1 Gene
RNA expression pattern
PBB GE HBQ1 220807 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3049 544763
Ensembl ENSG00000086506 ENSMUSG00000073063
UniProt P09105 Q8BYM1
RefSeq (mRNA) NM_005331 NM_001033981
RefSeq (protein) NP_005322 NP_001029153
Location (UCSC) Chr 16:
0.23 – 0.23 Mb
Chr 11:
32.29 – 32.29 Mb
PubMed search [1] [2]

Hemoglobin subunit theta-1 is a protein that in humans is encoded by the HBQ1 gene.[1][2]

Theta-globin mRNA is found in human fetal erythroid tissue but not in adult erythroid or other nonerythroid tissue. The theta-1 gene may be expressed very early in embryonic life, perhaps sometime before 5 weeks. Theta-1 is a member of the human alpha-globin gene cluster that involves five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta-1 - 3'. Research supports a transcriptionally active role for the gene and a functional role for the peptide in specific cells, possibly those of early erythroid tissue.[2]

References[edit]

  1. ^ Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ (May 1989). "A review of the molecular genetics of the human alpha-globin gene cluster". Blood 73 (5): 1081–104. PMID 2649166. 
  2. ^ a b "Entrez Gene: HBQ1 hemoglobin, theta 1". 

Further reading[edit]