Heffron has appeared on Comedy Central Presents, The Tonight Show with Jay Leno, and won the second season of Last Comic Standing. He appeared as contestant of the third season of Last Comic Standing ranking third place with Rich Vos overall and runner-up for Season 2.
He took a job as radio sidekick to Danny Bonaduce on a highly rated Detroit morning show on Q95-5 and did commentary on the 2004 VH1 TV series My Coolest Years: My First Time, and other VH1 shows. He toured with Charlie Murphy and Joe Rogan in Maxim and Bud Light's Real Men of Comedy tour in the fall of 2006.
He is married to Rie Heffron, who participated in the first season of reality show America's Toughest Jobs.
- "PEOPLE - John Heffron is voted the winner in Last Comic Standing". The Providence Journal. August 14, 2004. Retrieved 2010-11-01.
- Real Men of Comedy
- "phillyBurbs.com | Archive Search". Bucks County Courier Times. October 26, 2006. Retrieved 2010-11-01.