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Karissa Sanbonmatsu

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Karissa Y. Sanbonmatsu
Alma materColumbia University
University of Colorado Boulder
University of Cambridge
Known forStructural Biology
First simulation of the ribosome
First million atom simulation
First simulation of a gene
First billion atom simulation
First structural study of a lncRNA
Quasilinear-Zakharov modeling
AwardsPresidential Early Career Award for Scientists and Engineers
American Physical Society Fellow
Pembroke College Stokes Society Scientific Lecture Competition
Scientific career
InstitutionsLos Alamos National Laboratory
New Mexico Consortium
ThesisCompetition between Langmuir wave-wave and wave-particle interactions in the auroral ionosphere
Doctoral advisorMartin V. Goldman

Karissa Y. Sanbonmatsu is an American structural biologist at Los Alamos National Laboratory. She works on the mechanism of non-coding RNA complexes including the ribosome, riboswitches, long non-coding RNAs, as well as chromatin. She was the first to perform an atomistic simulation of the ribosome, determine the secondary structure of an intact lncRNA and to publish a one billion atom simulation of a biomolecular complex.[1]

Education and early career

Sanbonmatsu was born in Rochester, New York, the daughter of Joan Loveridge-Sanbonmatsu, and Akira Loveridge-Sanbonmatsu, who are both professors of speech communication in the State University of New York. She attended Oswego High School, and was valedictorian. She won the Pembroke College Stokes Society Scientific Lecture Competition at the University of Cambridge. Sanbonmatsu studied physics at Columbia University, where she used the Very Large Array radio telescope to estimate the distance to supernova remnant G27.4+0.0 and its central X-ray source,[2] which is now known to be a magnetar.[3][4] Karissa's early research was in plasma physics. She earned her PhD in astrophysical sciences at University of Colorado Boulder under Martin V. Goldman (a student of Donald F. Dubois). Her dissertation entailed analytical treatments of non-linear wave-wave interactions in plasmas, elucidating the competition between Langmuir wave-wave and wave-particle effects in the auroral ionosphere.[5][6][7] In 1997, after earning her doctorate, Sanbonmatsu joined Los Alamos National Laboratory as a postdoctoral scholar[4][8] under Donald F. Dubois (a student of Murray Gell-Mann), determining the effect of kinetic processes on Langmuir waves in plasmas.[9][10] She became interested in what distinguishes life from matter.[11] In 2002 Los Alamos built Q-machine, one of the world's fastest supercomputer.[11] The Q-machine allowed Sanbonmatsu to run the world's largest simulation in biology, publishing the first simulation of the ribosome in 2005, where she identified the “accommodation corridor” of the ribosome.[11][12]

Research

In 2006, Sanbonmatsu was the first transgender person at Los Alamos National Laboratory to be awarded the Presidential Early Career Award for Scientists and Engineers.[13] At the time, epigenetics was beginning to develop, and Sanbonmatsu realised that RNA could be involved in how genes are turned on and off.[11]

The Sanbonmatsu Laboratory at Los Alamos National Laboratory was established in 2001.[4] They use a variety of wet lab and computational techniques to study ribosomes, long non-coding RNA (lncRNAs), riboswitches[14][15] and chromatin. Sanbonmatsu has been a leading figure in structural studies of long non-coding RNAs in epigenetics. She studied COOLAIR, a stretch of RNA that controls the timing and flowering of plants.[16] It works by controlling the internal triggers that tell a plant to stop flowering, which work in combination with a repressor protein called Flowering Locus C.[16] When Sanbonmatsu studied the RNA structure, she found features that are similar to ribosomes.[16] In 2012 her group was the first to describe the secondary structure in a lncRNA; the steroid hormone receptor activator (SRA).[17] She went on to look at how the structure of RNA impacted the fate of a cell.[18] She uses illumina dye sequencing for high throughput SHAPE probing.[19]

The first billion atom simulation of an entire gene (GATA4).[1]

She develops computer simulations to understand tRNA translocation, combining single molecule fluorescence with cryogenic electron microscopy. Ribosomes undergo a dramatic change in structure when transfer RNA are passing through, and this was simulated computationally by Sanbonmatsu.[19] Sanbonmatsu has also written about gynandromorphism, and how DNA influences hormones, but hormone can reprogram DNA.[20] She was elected as a Fellow of the American Physical Society in 2012.[19] Most recently, her group set the record for the world’s largest published biomolecular simulation at one billion atoms, the first simulation of an entire gene.

Public engagement

She described her work with epigenetics and came out as transgender in a 2014 TEDxTalk.[21] Sanbonmatsu delivered a TED talk at TEDWomen on The biology of gender, from DNA to the brain, in November 2018.[22] In the talk she covered epigenetics, how DNA can change due to trauma and diet, and how her gender transition led her to study the role of epigenetics in gender identity. Sanbonmatsu has served on the board of Equality New Mexico.[23]

References

  1. ^ a b Jung, Jaewoon; Nishima, Wataru; Daniels, Marcus; Bascom, Gavin; Kobayashi, Chigusa; Adedoyin, Adetokunbo; Wall, Michael; Lappala, Anna; Phillips, Dominic; Fischer, William; Tung, Chang-Shung; Schlick, Tamar; Sugita, Yuji; Sanbonmatsu, Karissa (17 April 2019). "Scaling molecular dynamics beyond 100,000 processor cores for large‐scale biophysical simulations". Journal of Computational Chemistry. 40 (21): 1919–1930. doi:10.1002/jcc.25840. PMC 7153361. PMID 30994934.
  2. ^ Sanbonmatsu, K. Y.; Helfand, D. J. (1992-12-08). "A distance determination for the supernova remnant G27.4+0.0 and its central X-ray source". The Astronomical Journal. 104: 2189. Bibcode:1992AJ....104.2189S. doi:10.1086/116393.
  3. ^ Gao, Z. F.; Peng, Q. H.; Wang, N.; Yuan, J. P. (2012-11-09). "Magnetic field decay of magnetars in supernova remnants". Astrophysics and Space Science. 342 (1): 55–71. arXiv:1312.2679. Bibcode:2012Ap&SS.342...55G. doi:10.1007/s10509-012-1139-x. ISSN 0004-640X.
  4. ^ a b c "Keynotes - ACM SIGSOFT 2010 / FSE 18". fse18.cse.wustl.edu. Retrieved 2019-04-11.
  5. ^ Sanbonmatsu, K. Y.; Newman, D. L.; Goldman, M. V. (2001-06-01). "Quasi-linear Zakharov simulations of Langmuir turbulence at rocket altitudes in the auroral ionosphere". Journal of Geophysical Research: Space Physics. 106 (A6): 10519–10535. Bibcode:2001JGR...10610519S. doi:10.1029/2000JA000270.
  6. ^ Sanbonmatsu, K. Y.; Doxas, I.; Goldman, M. V.; Newman, D. L. (1997-04-01). "Non-Markovian electron diffusion in the auroral ionosphere at high Langmuir-wave intensities". Geophysical Research Letters. 24 (7): 807–810. Bibcode:1997GeoRL..24..807S. doi:10.1029/97GL00669.
  7. ^ Sanbonmatsu, K. Y.; Goldman, M. V.; Newman, D. L. (1995-09-01). "Nonlinear coupling of lower hybrid waves to the kinetic low-frequency plasma response in the auroral ionosphere". Geophysical Research Letters. 22 (17): 2397–2400. Bibcode:1995GeoRL..22.2397S. doi:10.1029/95GL02227.
  8. ^ Appel, Susanna (2017-08-29). "Fellows seminar series: New cryo-EM tools and new biochemical studies of long non-coding RNAs". SciLifeLab. Retrieved 2019-04-11.
  9. ^ Sanbonmatsu, K. Y.; Vu, H. X.; Bezzerides, B.; DuBois, D. F. (2000-05-02). "The effect of kinetic processes on Langmuir turbulence". Physics of Plasmas. 7 (5): 1723–1731. Bibcode:2000PhPl....7.1723S. doi:10.1063/1.873991. ISSN 1070-664X.
  10. ^ Sanbonmatsu, K.; Vu, H.; DuBois, D.; Bezzerides, B. (1999-02-03). "New Paradigm for the Self-Consistent Modeling of Wave-Particle and Wave-Wave Interactions in the Saturation of Electromagnetically Driven Parametric Instabilities". Physical Review Letters. 82 (5): 932–935. Bibcode:1999PhRvL..82..932S. doi:10.1103/PhysRevLett.82.932. ISSN 0031-9007.
  11. ^ a b c d Giorgi, Elena E.; Photographer, ContributorScientist Writer (2016-02-15). "Decoding the Dark Matter of the Human Genome". HuffPost. Retrieved 2019-04-11. {{cite web}}: |first2= has generic name (help)
  12. ^ Sanbonmatsu, K. Y.; Joseph, S.; Tung, C.-S. (2005-11-01). "Simulating movement of tRNA into the ribosome during decoding". Proceedings of the National Academy of Sciences. 102 (44): 15854–15859. Bibcode:2005PNAS..10215854S. doi:10.1073/pnas.0503456102. ISSN 0027-8424. PMC 1266076. PMID 16249344.
  13. ^ Energy, Los Alamos National Laboratory, Operated by Los Alamos National Security, LLC, for the U. S. Department of. "Presidential Early Career Awards for Scientists and Engineers (PECASE)". www.lanl.gov. Retrieved 2019-04-11.{{cite web}}: CS1 maint: multiple names: authors list (link)
  14. ^ "Sanbonmatsu Team: Models". www.lanl.gov. Retrieved 2019-04-11.
  15. ^ "Sanbonmatsu Team: People". www.lanl.gov. Retrieved 2019-04-11.
  16. ^ a b c "New insights into 'plant memories'". ScienceDaily. Retrieved 2019-04-11.
  17. ^ Chi, Kelly Rae (2016-01-20). "Finding function in mystery transcripts". Nature. 529 (7586): 423–425. Bibcode:2016Natur.529..423C. doi:10.1038/529423a. ISSN 1476-4687. PMID 26791729.
  18. ^ "Linking RNA structure and function". MIT News. Retrieved 2019-04-11.
  19. ^ a b c "Research Objectives" (PDF). Research Features. Retrieved 2019-04-12.
  20. ^ Weintraub, Karen (2019-02-25). "Split-Sex Animals Are Unusual, Yes, but Not as Rare as You'd Think". The New York Times. ISSN 0362-4331. Retrieved 2019-04-12.
  21. ^ Sanbonmatsu, Karissa. "How You Know You're in Love: Epigenetics, Stress & Gender Identity". YouTube. Retrieved 13 April 2019.
  22. ^ Sanbonmatsu, Karissa, The biology of gender, from DNA to the brain, retrieved 2019-04-11
  23. ^ "EQNM Board". Equality New Mexico. Retrieved 2021-05-29.

TED Talk - The biology of gender, from DNA to the brain

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